Detailed information of TA system TA226979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4526624..4527231
• Replicon: chromosome
• Accession: NZ_CP088221
• Organism: Enterobacter hormaechei strain Eh60

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A4Q4AAS0
• Locus tag: LK764_RS21830
• Protein ID: WP_057979982.1
• Coordinates: 4527046..4527231 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LK764_RS21825
• Protein ID: WP_023315016.1
• Coordinates: 4526624..4527031 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK764_RS21810 (LK764_21865)	4523368..4524621	+	1254	WP_015572749.1	valine--pyruvate transaminase	-
LK764_RS21815 (LK764_21870)	4524629..4525084	-	456	WP_045343649.1	4Fe-4S dicluster domain-containing protein	-
LK764_RS21820 (LK764_21875)	4525544..4526620	+	1077	WP_023323870.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
LK764_RS21825 (LK764_21880)	4526624..4527031	-	408	WP_023315016.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LK764_RS21830 (LK764_21885)	4527046..4527231	-	186	WP_057979982.1	type II toxin-antitoxin system HicA family toxin	Toxin
LK764_RS21835 (LK764_21890)	4527481..4529019	-	1539	WP_006808612.1	aldehyde dehydrogenase AldB	-
LK764_RS21840 (LK764_21895)	4529186..4530070	+	885	WP_003860164.1	ROK family protein	-
LK764_RS21845 (LK764_21900)	4530074..4531912	-	1839	WP_220153430.1	selenocysteine-specific translation elongation factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6852.08 Da
• Isoelectric Point: 11.5191

>T226979 WP_057979982.1 NZ_CP088221:c4527231-4527046 [Enterobacter hormaechei]
VKSADIITVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T226979 NZ_CP122673:c4003940-4003542 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15205.20 Da
• Isoelectric Point: 4.5036

>AT226979 WP_023315016.1 NZ_CP088221:c4527031-4526624 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEMLPLPGMVEAHLASHPEDFIGGQWL
LVDINMKQFEGRVERINITIPRRLLVKIDSFVSEHPQFTNRSAFLAEAARRVLPR

Nucleotide

• Length: 408 bp

>AT226979 NZ_CP122673:c4004236-4003943 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A4Q4AAS0