Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3072910..3074693 Replicon chromosome
Accession NZ_CP088221
Organism Enterobacter hormaechei strain Eh60

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LK764_RS14795 Protein ID WP_023314540.1
Coordinates 3072910..3074259 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A837FFV9
Locus tag LK764_RS14800 Protein ID WP_003859317.1
Coordinates 3074256..3074693 (+) Length 146 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK764_RS14770 (LK764_14810) 3068733..3069668 - 936 WP_045343060.1 tRNA dihydrouridine(16) synthase DusC -
LK764_RS14775 (LK764_14815) 3069837..3070232 + 396 WP_003859308.1 CidA/LrgA family protein -
LK764_RS14780 (LK764_14820) 3070229..3070924 + 696 WP_003859310.1 CidB/LrgB family autolysis modulator -
LK764_RS14785 (LK764_14825) 3071053..3071937 + 885 WP_003859312.1 cytidine deaminase -
LK764_RS14790 (LK764_14830) 3072065..3072775 + 711 WP_003859314.1 outer membrane permeability protein SanA -
LK764_RS14795 (LK764_14835) 3072910..3074259 + 1350 WP_023314540.1 HipA domain-containing protein Toxin
LK764_RS14800 (LK764_14840) 3074256..3074693 + 438 WP_003859317.1 helix-turn-helix transcriptional regulator Antitoxin
LK764_RS14805 (LK764_14845) 3074732..3075742 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
LK764_RS14810 (LK764_14850) 3075758..3077278 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
LK764_RS14815 (LK764_14855) 3077358..3078356 - 999 WP_017383382.1 galactose/glucose ABC transporter substrate-binding protein MglB -
LK764_RS14820 (LK764_14860) 3078652..3079674 - 1023 WP_045337656.1 HTH-type transcriptional regulator GalS -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(166-406)

Antitoxin

(75-128)


Sequences


Toxin        


Download         Length: 450 a.a.        Molecular weight: 51137.78 Da        Isoelectric Point: 4.6562

>T226977 WP_023314540.1 NZ_CP088221:3072910-3074259 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

>T226977 NZ_CP122673:3780459-3780677 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16185.64 Da        Isoelectric Point: 10.5154

>AT226977 WP_003859317.1 NZ_CP088221:3074256-3074693 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp

>AT226977 NZ_CP122673:3780059-3780433 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A837FFV9

References