Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2261091..2261830 Replicon chromosome
Accession NZ_CP088221
Organism Enterobacter hormaechei strain Eh60

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag LK764_RS10845 Protein ID WP_220153839.1
Coordinates 2261091..2261576 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A927HKN6
Locus tag LK764_RS10850 Protein ID WP_045336276.1
Coordinates 2261564..2261830 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK764_RS10820 (LK764_10845) 2256174..2257466 + 1293 WP_045342950.1 glycosyl hydrolase family 28 protein -
LK764_RS10825 (LK764_10850) 2257762..2258214 - 453 WP_250018378.1 hypothetical protein -
LK764_RS10830 (LK764_10855) 2258293..2258709 - 417 WP_250018380.1 hypothetical protein -
LK764_RS10835 (LK764_10860) 2259525..2259884 - 360 WP_220153837.1 hypothetical protein -
LK764_RS10840 (LK764_10865) 2259902..2260840 - 939 WP_220153838.1 hypothetical protein -
LK764_RS10845 (LK764_10870) 2261091..2261576 - 486 WP_220153839.1 GNAT family N-acetyltransferase Toxin
LK764_RS10850 (LK764_10875) 2261564..2261830 - 267 WP_045336276.1 DUF1778 domain-containing protein Antitoxin
LK764_RS10855 (LK764_10880) 2261894..2262823 - 930 WP_126524894.1 LysR family transcriptional regulator -
LK764_RS10860 (LK764_10885) 2262953..2264341 + 1389 WP_063401776.1 MFS transporter -
LK764_RS10865 (LK764_10890) 2264363..2265358 - 996 WP_126524895.1 DUF2891 domain-containing protein -
LK764_RS10870 (LK764_10895) 2265368..2266354 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17526.21 Da        Isoelectric Point: 9.9658

>T226968 WP_220153839.1 NZ_CP088221:c2261576-2261091 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLGEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLGTGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T226968 NZ_CP122673:1970063-1970317 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10032.46 Da        Isoelectric Point: 4.4857

>AT226968 WP_045336276.1 NZ_CP088221:c2261830-2261564 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWGV

Download         Length: 267 bp

>AT226968 NZ_CP122673:1969815-1970066 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCTGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References