Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1091591..1092211 Replicon chromosome
Accession NZ_CP088221
Organism Enterobacter hormaechei strain Eh60

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag LK764_RS05210 Protein ID WP_015571250.1
Coordinates 1091591..1091809 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LK764_RS05215 Protein ID WP_006809850.1
Coordinates 1091837..1092211 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK764_RS05180 (LK764_05190) 1087616..1087876 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
LK764_RS05185 (LK764_05195) 1087879..1088019 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LK764_RS05190 (LK764_05200) 1088016..1088726 - 711 WP_022650493.1 GNAT family protein -
LK764_RS05195 (LK764_05205) 1088828..1090275 + 1448 Protein_1004 PLP-dependent aminotransferase family protein -
LK764_RS05200 (LK764_05210) 1090247..1090714 - 468 WP_022650495.1 YlaC family protein -
LK764_RS05205 (LK764_05215) 1090831..1091382 - 552 WP_022650496.1 maltose O-acetyltransferase -
LK764_RS05210 (LK764_05220) 1091591..1091809 - 219 WP_015571250.1 HHA domain-containing protein Toxin
LK764_RS05215 (LK764_05225) 1091837..1092211 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
LK764_RS05220 (LK764_05230) 1092721..1095867 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
LK764_RS05225 (LK764_05235) 1095890..1097083 - 1194 WP_220153614.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T226966 WP_015571250.1 NZ_CP088221:c1091809-1091591 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T226966 NZ_CP122673:1138412-1138723 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAATAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT226966 WP_006809850.1 NZ_CP088221:c1092211-1091837 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT226966 NZ_CP122673:1138720-1139139 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGATACTAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAATAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References