Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 944473..945212 Replicon chromosome
Accession NZ_CP088221
Organism Enterobacter hormaechei strain Eh60

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag LK764_RS04490 Protein ID WP_007791075.1
Coordinates 944473..944838 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag LK764_RS04495 Protein ID WP_032976998.1
Coordinates 944874..945212 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK764_RS04465 (LK764_04475) 939654..940055 + 402 WP_220153595.1 sigma factor-binding protein Crl -
LK764_RS04470 (LK764_04480) 940188..941240 - 1053 WP_003863199.1 phosphoporin PhoE -
LK764_RS04475 (LK764_04485) 941546..942649 + 1104 WP_015571369.1 glutamate 5-kinase -
LK764_RS04480 (LK764_04490) 942661..943914 + 1254 WP_023315480.1 glutamate-5-semialdehyde dehydrogenase -
LK764_RS04490 (LK764_04500) 944473..944838 - 366 WP_007791075.1 TA system toxin CbtA family protein Toxin
LK764_RS04495 (LK764_04505) 944874..945212 - 339 WP_032976998.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LK764_RS04500 (LK764_04510) 945228..945449 - 222 WP_220153596.1 DUF987 family protein -
LK764_RS04505 (LK764_04515) 945446..945946 - 501 WP_050555520.1 DNA repair protein RadC -
LK764_RS04510 (LK764_04520) 945976..946794 - 819 WP_058690954.1 DUF932 domain-containing protein -
LK764_RS04515 (LK764_04525) 946894..947571 - 678 WP_058690953.1 hypothetical protein -
LK764_RS04520 (LK764_04530) 947857..948750 - 894 WP_032977003.1 YfjP family GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(10-111)

Antitoxin

Antitoxin CbeA

(9-108)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13555.58 Da        Isoelectric Point: 9.6231

>T226965 WP_007791075.1 NZ_CP088221:c944838-944473 [Enterobacter hormaechei]
MQISTAPTTVPVSSRLSPIEVWQILLKHLLAQHYGLTLNDTPFSDESTIREHINAGISLSNAVNFIVEKYELVRTDRSGF
TIMEQSPFISSIDILRARRATGLMKRQGYKSISNITTGHLL

Download         Length: 366 bp

>T226965 NZ_CP122673:911667-912074 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12460.03 Da        Isoelectric Point: 5.5372

>AT226965 WP_032976998.1 NZ_CP088221:c945212-944874 [Enterobacter hormaechei]
MTKEPVQEHVWGLHSQTVPSFSARLVQEGRRLHFLADRATLLGTFSPEQSTALDAIFPALTQDMETALLSGKLDPREAKQ
YIHTRNGFACESDTLGSCGYVYIVIYPQSETS

Download         Length: 339 bp

>AT226965 NZ_CP122673:911420-911686 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References