226963

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1983294..1983756 Replicon chromosome
Accession NZ_CP088218
Organism Staphylococcus sp. HL28

Toxin (Protein)


Gene name TsaT Uniprot ID A0A2V3ZEQ2
Locus tag LPC11_RS09635 Protein ID WP_002465948.1
Coordinates 1983571..1983756 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A2V3ZER2
Locus tag LPC11_RS09630 Protein ID WP_023374884.1
Coordinates 1983294..1983551 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC11_RS09590 (LPC11_09590) 1978505..1978828 + 324 WP_023374890.1 thioredoxin family protein -
LPC11_RS09595 (LPC11_09595) 1978938..1979477 - 540 WP_002465937.1 nitroreductase -
LPC11_RS09600 (LPC11_09600) 1979555..1980271 - 717 WP_231307233.1 type I 3-dehydroquinate dehydratase -
LPC11_RS09605 (LPC11_09605) 1980448..1980870 + 423 WP_002450862.1 organic hydroperoxide resistance protein -
LPC11_RS09610 (LPC11_09610) 1981147..1981641 + 495 WP_023374887.1 GNAT family N-acetyltransferase -
LPC11_RS09615 (LPC11_09615) 1981774..1982364 - 591 WP_041613887.1 histidine phosphatase family protein -
LPC11_RS09620 (LPC11_09620) 1982572..1982805 + 234 WP_231307234.1 hypothetical protein -
LPC11_RS09625 (LPC11_09625) 1982797..1983000 - 204 WP_015365249.1 sterile alpha motif-like domain-containing protein -
LPC11_RS09630 (LPC11_09630) 1983294..1983551 + 258 WP_023374884.1 hypothetical protein Antitoxin
LPC11_RS09635 (LPC11_09635) 1983571..1983756 + 186 WP_002465948.1 hypothetical protein Toxin
LPC11_RS09640 (LPC11_09640) 1983962..1984438 + 477 WP_226956339.1 lipoprotein N-acylation protein LnsA -
LPC11_RS09645 (LPC11_09645) 1984498..1984731 - 234 WP_002450870.1 hypothetical protein -
LPC11_RS09650 (LPC11_09650) 1984984..1985730 + 747 WP_231307235.1 poly-gamma-glutamate hydrolase family protein -
LPC11_RS09655 (LPC11_09655) 1985821..1986105 + 285 WP_231307236.1 hypothetical protein -
LPC11_RS09660 (LPC11_09660) 1986183..1986398 + 216 WP_023374880.1 hypothetical protein -
LPC11_RS09665 (LPC11_09665) 1986859..1987098 + 240 WP_023374879.1 hypothetical protein -
LPC11_RS09670 (LPC11_09670) 1987326..1987559 + 234 WP_023374878.1 hypothetical protein -
LPC11_RS09675 (LPC11_09675) 1987733..1987933 - 201 WP_002450876.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6977.68 Da        Isoelectric Point: 10.1605

>T226963 WP_002465948.1 NZ_CP088218:1983571-1983756 [Staphylococcus sp. HL28]
MSLHFTILFWLSLIFIVAGAIILAIMLKTKKESKKESYLGFTIVFFIFGLAMLIYTLLFGL

Download         Length: 186 bp

>T226963 NZ_CP122673:c618357-617893 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATAGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCTTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCGATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9896.08 Da        Isoelectric Point: 4.1911

>AT226963 WP_023374884.1 NZ_CP088218:1983294-1983551 [Staphylococcus sp. HL28]
MKLYIIHAINIIITILFIIFNVIITYNTNLDDTLWLVPGLIVCGLIMMISFGIAISNKDLLSEVLFFINIILTLYYIYPI
FYDFL

Download         Length: 258 bp

>AT226963 NZ_CP122673:c618692-618357 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3ZEQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A2V3ZER2

References