Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1012380..1013186 Replicon chromosome
Accession NZ_CP088218
Organism Staphylococcus sp. HL28

Toxin (Protein)


Gene name tsbT Uniprot ID A0A364UNB4
Locus tag LPC11_RS05005 Protein ID WP_002466824.1
Coordinates 1013007..1013186 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A2V3ZD14
Locus tag LPC11_RS05000 Protein ID WP_023373067.1
Coordinates 1012380..1012979 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC11_RS04980 (LPC11_04980) 1008169..1009629 + 1461 WP_023373075.1 ABC transporter substrate-binding protein/permease -
LPC11_RS04985 (LPC11_04985) 1009622..1010344 + 723 WP_023373073.1 amino acid ABC transporter ATP-binding protein -
LPC11_RS04990 (LPC11_04990) 1010600..1011733 + 1134 WP_023373071.1 tRNA epoxyqueuosine(34) reductase QueG -
LPC11_RS04995 (LPC11_04995) 1011730..1012200 + 471 WP_023373069.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LPC11_RS05000 (LPC11_05000) 1012380..1012979 + 600 WP_023373067.1 glucosamine-6-phosphate isomerase Antitoxin
LPC11_RS05005 (LPC11_05005) 1013007..1013186 + 180 WP_002466824.1 SAS053 family protein Toxin
LPC11_RS05010 (LPC11_05010) 1013330..1013722 + 393 WP_023373063.1 hypothetical protein -
LPC11_RS05015 (LPC11_05015) 1013876..1015261 + 1386 WP_023373062.1 class II fumarate hydratase -
LPC11_RS05020 (LPC11_05020) 1015320..1016150 - 831 WP_023373060.1 RluA family pseudouridine synthase -
LPC11_RS05025 (LPC11_05025) 1016328..1017440 + 1113 WP_023373058.1 GAF domain-containing sensor histidine kinase -
LPC11_RS05030 (LPC11_05030) 1017461..1018084 + 624 WP_023373056.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6901.22 Da        Isoelectric Point: 3.8441

>T226959 WP_002466824.1 NZ_CP088218:1013007-1013186 [Staphylococcus sp. HL28]
MTQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEEKLNQSHDSDVRSDLDQD

Download         Length: 180 bp

>T226959 NZ_CP122662:62230-62508 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22624.58 Da        Isoelectric Point: 5.3571

>AT226959 WP_023373067.1 NZ_CP088218:1012380-1012979 [Staphylococcus sp. HL28]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDKNQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDENGHLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT226959 NZ_CP122662:61961-62230 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364UNB4

Antitoxin

Source ID Structure
AlphaFold DB A0A2V3ZD14

References