226958

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 870245..870774 Replicon chromosome
Accession NZ_CP088218
Organism Staphylococcus sp. HL28

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PXE7
Locus tag LPC11_RS04195 Protein ID WP_002451625.1
Coordinates 870412..870774 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag LPC11_RS04190 Protein ID WP_002451626.1
Coordinates 870245..870415 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC11_RS04165 (LPC11_04165) 866070..866543 + 474 WP_023373293.1 PH domain-containing protein -
LPC11_RS04170 (LPC11_04170) 866536..868062 + 1527 WP_023373291.1 PH domain-containing protein -
LPC11_RS04175 (LPC11_04175) 868175..868546 + 372 WP_226956363.1 PH domain-containing protein -
LPC11_RS04180 (LPC11_04180) 868579..868953 + 375 WP_023373287.1 holo-ACP synthase -
LPC11_RS04185 (LPC11_04185) 869005..870153 + 1149 WP_231307362.1 alanine racemase -
LPC11_RS04190 (LPC11_04190) 870245..870415 + 171 WP_002451626.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LPC11_RS04195 (LPC11_04195) 870412..870774 + 363 WP_002451625.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LPC11_RS04200 (LPC11_04200) 871100..872101 + 1002 WP_023373284.1 PP2C family protein-serine/threonine phosphatase -
LPC11_RS04205 (LPC11_04205) 872196..872522 + 327 WP_002466754.1 anti-sigma factor antagonist -
LPC11_RS04210 (LPC11_04210) 872524..873003 + 480 WP_002466768.1 anti-sigma B factor RsbW -
LPC11_RS04215 (LPC11_04215) 872978..873748 + 771 WP_002451621.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13562.68 Da        Isoelectric Point: 9.9783

>T226958 WP_002451625.1 NZ_CP088218:870412-870774 [Staphylococcus sp. HL28]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFNHSKT

Download         Length: 363 bp

>T226958 NZ_CP122662:7610-7762 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT226958 WP_002451626.1 NZ_CP088218:870245-870415 [Staphylococcus sp. HL28]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp

>AT226958 NZ_CP122662:c7555-7498 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PXE7

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References