Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 859123..859633 Replicon chromosome
Accession NZ_CP088218
Organism Staphylococcus sp. HL28

Toxin (Protein)


Gene name TsdT Uniprot ID A0A2V3Z9H5
Locus tag LPC11_RS04135 Protein ID WP_023373301.1
Coordinates 859427..859633 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A364UNN3
Locus tag LPC11_RS04130 Protein ID WP_002466760.1
Coordinates 859123..859416 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC11_RS04105 (LPC11_04105) 854253..855044 + 792 WP_023373308.1 hydroxyethylthiazole kinase -
LPC11_RS04110 (LPC11_04110) 855045..855686 + 642 WP_023373306.1 thiamine phosphate synthase -
LPC11_RS04115 (LPC11_04115) 855775..856644 + 870 WP_002466746.1 membrane protein insertase YidC -
LPC11_RS04120 (LPC11_04120) 856684..857328 - 645 WP_023373305.1 HD domain-containing protein -
LPC11_RS04125 (LPC11_04125) 857450..858934 - 1485 WP_023373303.1 cardiolipin synthase -
LPC11_RS04130 (LPC11_04130) 859123..859416 + 294 WP_002466760.1 copper-sensing transcriptional repressor CsoR Antitoxin
LPC11_RS04135 (LPC11_04135) 859427..859633 + 207 WP_023373301.1 heavy metal-associated domain-containing protein Toxin
LPC11_RS04140 (LPC11_04140) 859772..859909 + 138 WP_002466770.1 Lmo0850 family protein -
LPC11_RS04145 (LPC11_04145) 860049..861239 - 1191 WP_023373299.1 FtsW/RodA/SpoVE family cell cycle protein -
LPC11_RS04150 (LPC11_04150) 861596..862666 + 1071 WP_023373297.1 D-alanine--D-alanine ligase -
LPC11_RS04155 (LPC11_04155) 862682..864043 + 1362 WP_023373295.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7628.58 Da        Isoelectric Point: 4.0101

>T226957 WP_023373301.1 NZ_CP088218:859427-859633 [Staphylococcus sp. HL28]
VQQKIVYTAGIETQEQSDAIKNLLTEMIGVHQVEIDINTGNISIEFETPANLNSIEKEIYDAGFKVLY

Download         Length: 207 bp

>T226957 NZ_CP122661:c8166-7900 [Escherichia coli]
ATGAAGGTACGAAAAGGTGACAGGCAATATTATTTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGGAAAACAAAAGCGACAGTGATAACTGTTGCCGATCTGATTTTTCATGAAGATGCAT
TCGACACTATCGACTTTACCAGAGGCGGGTTAAGAGAGAACGACAAAGAAGTTGTTTCTATGATGATTCAGGAAATGAAC
AATGAACGAGAAAAAAATGTTAACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11199.74 Da        Isoelectric Point: 6.3263

>AT226957 WP_002466760.1 NZ_CP088218:859123-859416 [Staphylococcus sp. HL28]
VTEQDHAHHSEQIKVNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIADKVNQGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT226957 NZ_CP122661:c7910-7668 [Escherichia coli]
ATGTTAACTGAAAATACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACGCAAAGAGAATGTGCTGAAAT
ATTCAGCATGAACCCGCGAACCTGGCGTCGCAAGGAAGAACCTGCCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATATCTTCAGCTTTTAGCTGGGGAACATCCTGAATACGTTCTGCGCAAAAGGGATAAACCTAAATGTAGTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3Z9H5

Antitoxin

Source ID Structure
AlphaFold DB A0A364UNN3

References