Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2311439..2312046 Replicon chromosome
Accession NZ_CP088203
Organism Enterococcus durans strain S8-3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LQ052_RS10770 Protein ID WP_081134843.1
Coordinates 2311439..2311789 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LQ052_RS10775 Protein ID WP_081134844.1
Coordinates 2311783..2312046 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ052_RS10755 (LQ052_10755) 2307754..2309004 + 1251 WP_081134838.1 SPFH domain-containing protein -
LQ052_RS10760 (LQ052_10760) 2309027..2310238 + 1212 WP_081134840.1 ATP-binding protein -
LQ052_RS10765 (LQ052_10765) 2310235..2311032 + 798 WP_081134841.1 TPM domain-containing protein -
LQ052_RS10770 (LQ052_10770) 2311439..2311789 - 351 WP_081134843.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LQ052_RS10775 (LQ052_10775) 2311783..2312046 - 264 WP_081134844.1 PbsX family transcriptional regulator Antitoxin
LQ052_RS10780 (LQ052_10780) 2312390..2313046 - 657 WP_005878251.1 Crp/Fnr family transcriptional regulator -
LQ052_RS10785 (LQ052_10785) 2313239..2313517 + 279 WP_081134846.1 hypothetical protein -
LQ052_RS10790 (LQ052_10790) 2313536..2314723 + 1188 WP_081134847.1 MFS transporter -
LQ052_RS10795 (LQ052_10795) 2315061..2315387 - 327 WP_016177343.1 MazG-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin

Antitoxin PemI-like

(4-87)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13240.22 Da        Isoelectric Point: 8.0294

>T226955 WP_081134843.1 NZ_CP088203:c2311789-2311439 [Enterococcus durans]
MVRNPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVTVAPISSTTRNYPLYVNINSQYEMKTTGKVLLDQLT
TIDYEARECIFLEKAHDSLVEELLMKVRTVFQKVSK

Download         Length: 351 bp

>T226955 NZ_CP122660:c4319562-4319389 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10171.55 Da        Isoelectric Point: 4.6865

>AT226955 WP_081134844.1 NZ_CP088203:c2312046-2311783 [Enterococcus durans]
MEMLPIKKWGNSNGLRLPKYIMEYLGIHTEDKVKITQEEVNGQKRLIIEAANLENELTIEQLFENYTDERNHVTIQNLGE
AVGNEKW

Download         Length: 264 bp

>AT226955 NZ_CP122660:c4319886-4319590 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References