Detailed information of TA system TA226955

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 2311439..2312046
• Replicon: chromosome
• Accession: NZ_CP088203
• Organism: Enterococcus durans strain S8-3

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: LQ052_RS10770
• Protein ID: WP_081134843.1
• Coordinates: 2311439..2311789 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: LQ052_RS10775
• Protein ID: WP_081134844.1
• Coordinates: 2311783..2312046 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ052_RS10755 (LQ052_10755)	2307754..2309004	+	1251	WP_081134838.1	SPFH domain-containing protein	-
LQ052_RS10760 (LQ052_10760)	2309027..2310238	+	1212	WP_081134840.1	ATP-binding protein	-
LQ052_RS10765 (LQ052_10765)	2310235..2311032	+	798	WP_081134841.1	TPM domain-containing protein	-
LQ052_RS10770 (LQ052_10770)	2311439..2311789	-	351	WP_081134843.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
LQ052_RS10775 (LQ052_10775)	2311783..2312046	-	264	WP_081134844.1	PbsX family transcriptional regulator	Antitoxin
LQ052_RS10780 (LQ052_10780)	2312390..2313046	-	657	WP_005878251.1	Crp/Fnr family transcriptional regulator	-
LQ052_RS10785 (LQ052_10785)	2313239..2313517	+	279	WP_081134846.1	hypothetical protein	-
LQ052_RS10790 (LQ052_10790)	2313536..2314723	+	1188	WP_081134847.1	MFS transporter	-
LQ052_RS10795 (LQ052_10795)	2315061..2315387	-	327	WP_016177343.1	MazG-like family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-111)

Antitoxin

• Antitoxin PemI-like (4-87)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13240.22 Da
• Isoelectric Point: 8.0294

>T226955 WP_081134843.1 NZ_CP088203:c2311789-2311439 [Enterococcus durans]
MVRNPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVTVAPISSTTRNYPLYVNINSQYEMKTTGKVLLDQLT
TIDYEARECIFLEKAHDSLVEELLMKVRTVFQKVSK

Nucleotide

• Length: 351 bp

>T226955 NZ_CP122660:c4319562-4319389 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10171.55 Da
• Isoelectric Point: 4.6865

>AT226955 WP_081134844.1 NZ_CP088203:c2312046-2311783 [Enterococcus durans]
MEMLPIKKWGNSNGLRLPKYIMEYLGIHTEDKVKITQEEVNGQKRLIIEAANLENELTIEQLFENYTDERNHVTIQNLGE
AVGNEKW

Nucleotide

• Length: 264 bp

>AT226955 NZ_CP122660:c4319886-4319590 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG