226954

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1800775..1801268 Replicon chromosome
Accession NZ_CP088203
Organism Enterococcus durans strain S8-3

Toxin (Protein)


Gene name relE Uniprot ID A0A2A7SNY0
Locus tag LQ052_RS08250 Protein ID WP_005880058.1
Coordinates 1800775..1801041 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2A7SN65
Locus tag LQ052_RS08255 Protein ID WP_005880060.1
Coordinates 1801038..1801268 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ052_RS08220 (LQ052_08220) 1796128..1797300 - 1173 WP_081135511.1 radical SAM family heme chaperone HemW -
LQ052_RS08225 (LQ052_08225) 1797631..1799013 - 1383 WP_081135508.1 site-specific integrase -
LQ052_RS08230 (LQ052_08230) 1799186..1799419 - 234 WP_081135506.1 DUF3850 domain-containing protein -
LQ052_RS08235 (LQ052_08235) 1799491..1800039 - 549 WP_081135503.1 hypothetical protein -
LQ052_RS08240 (LQ052_08240) 1800036..1800230 - 195 WP_081135501.1 hypothetical protein -
LQ052_RS08245 (LQ052_08245) 1800214..1800657 - 444 WP_179135161.1 conjugal transfer protein -
LQ052_RS08250 (LQ052_08250) 1800775..1801041 - 267 WP_005880058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ052_RS08255 (LQ052_08255) 1801038..1801268 - 231 WP_005880060.1 DUF6290 family protein Antitoxin
LQ052_RS08260 (LQ052_08260) 1801524..1801631 + 108 WP_227326304.1 putative holin-like toxin -
LQ052_RS08265 (LQ052_08265) 1801867..1802085 - 219 WP_081135496.1 hypothetical protein -
LQ052_RS08270 (LQ052_08270) 1802257..1802520 - 264 WP_081135493.1 hypothetical protein -
LQ052_RS08275 (LQ052_08275) 1802622..1803380 - 759 WP_005880068.1 restriction endonuclease -
LQ052_RS08280 (LQ052_08280) 1803713..1804738 - 1026 WP_016176475.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10563.16 Da        Isoelectric Point: 10.0944

>T226954 WP_005880058.1 NZ_CP088203:c1801041-1800775 [Enterococcus durans]
VTYHLEFTPEIQKQLRKMDKYQATLIVRWLYQHIDGVDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDNQMVVIAIQV
GHRRNVYD

Download         Length: 267 bp

>T226954 NZ_CP122660:3751746-3752024 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8850.03 Da        Isoelectric Point: 4.2583

>AT226954 WP_005880060.1 NZ_CP088203:c1801268-1801038 [Enterococcus durans]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWIESGKPTVSMEEILNEFGGLK

Download         Length: 231 bp

>AT226954 NZ_CP122660:3751483-3751743 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A7SNY0

Antitoxin

Source ID Structure
AlphaFold DB A0A2A7SN65

References