Detailed information of TA system TA226953

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 164021..164631
• Replicon: chromosome
• Accession: NZ_CP088203
• Organism: Enterococcus durans strain S8-3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LQ052_RS00820
• Protein ID: WP_179135125.1
• Coordinates: 164021..164209 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LQ052_RS00825
• Protein ID: WP_081133751.1
• Coordinates: 164245..164631 (+)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ052_RS00810 (LQ052_00810)	160925..163015	+	2091	WP_081133749.1	DNA mismatch repair endonuclease MutL	-
LQ052_RS00815 (LQ052_00815)	163034..163591	+	558	WP_081133750.1	Maf family protein	-
LQ052_RS00820 (LQ052_00820)	164021..164209	+	189	WP_179135125.1	type II toxin-antitoxin system HicA family toxin	Toxin
LQ052_RS00825 (LQ052_00825)	164245..164631	+	387	WP_081133751.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LQ052_RS00830 (LQ052_00830)	164948..166933	-	1986	WP_081133752.1	PTS system trehalose-specific EIIBC component	-
LQ052_RS00835 (LQ052_00835)	167170..167883	+	714	WP_005875275.1	trehalose operon repressor	-
LQ052_RS00840 (LQ052_00840)	167960..168400	+	441	WP_081133753.1	peptide-methionine (R)-S-oxide reductase MsrB	-
LQ052_RS00845 (LQ052_00845)	169012..169614	+	603	WP_081133754.1	Holliday junction branch migration protein RuvA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-103)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7020.30 Da
• Isoelectric Point: 10.7808

>T226953 WP_179135125.1 NZ_CP088203:164021-164209 [Enterococcus durans]
MPMTIREAEKLLKEAGFVEVKGGKGSHRKFIKENFPRPVILTCHSKELSQRVENTVRKAVGL

Nucleotide

• Length: 189 bp

>T226953 NZ_CP122660:c3745684-3745286 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 14289.47 Da
• Isoelectric Point: 4.3660

>AT226953 WP_081133751.1 NZ_CP088203:164245-164631 [Enterococcus durans]
MKKVYPAIFEKDPVGYGIYFPDVEGAVTQAETILEGLEVASDALGIMLGDLVERNLPLPEPSTMKEISYDPETEFATLVS
VELDDYLKDVKLDKKTIKIPHWLNVRATNEGINFSKTMTEALAKKLNI

Nucleotide

• Length: 387 bp

>AT226953 NZ_CP122660:c3745980-3745687 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA