Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 164021..164631 Replicon chromosome
Accession NZ_CP088203
Organism Enterococcus durans strain S8-3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LQ052_RS00820 Protein ID WP_179135125.1
Coordinates 164021..164209 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LQ052_RS00825 Protein ID WP_081133751.1
Coordinates 164245..164631 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ052_RS00810 (LQ052_00810) 160925..163015 + 2091 WP_081133749.1 DNA mismatch repair endonuclease MutL -
LQ052_RS00815 (LQ052_00815) 163034..163591 + 558 WP_081133750.1 Maf family protein -
LQ052_RS00820 (LQ052_00820) 164021..164209 + 189 WP_179135125.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ052_RS00825 (LQ052_00825) 164245..164631 + 387 WP_081133751.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ052_RS00830 (LQ052_00830) 164948..166933 - 1986 WP_081133752.1 PTS system trehalose-specific EIIBC component -
LQ052_RS00835 (LQ052_00835) 167170..167883 + 714 WP_005875275.1 trehalose operon repressor -
LQ052_RS00840 (LQ052_00840) 167960..168400 + 441 WP_081133753.1 peptide-methionine (R)-S-oxide reductase MsrB -
LQ052_RS00845 (LQ052_00845) 169012..169614 + 603 WP_081133754.1 Holliday junction branch migration protein RuvA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-103)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7020.30 Da        Isoelectric Point: 10.7808

>T226953 WP_179135125.1 NZ_CP088203:164021-164209 [Enterococcus durans]
MPMTIREAEKLLKEAGFVEVKGGKGSHRKFIKENFPRPVILTCHSKELSQRVENTVRKAVGL

Download         Length: 189 bp

>T226953 NZ_CP122660:c3745684-3745286 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 14289.47 Da        Isoelectric Point: 4.3660

>AT226953 WP_081133751.1 NZ_CP088203:164245-164631 [Enterococcus durans]
MKKVYPAIFEKDPVGYGIYFPDVEGAVTQAETILEGLEVASDALGIMLGDLVERNLPLPEPSTMKEISYDPETEFATLVS
VELDDYLKDVKLDKKTIKIPHWLNVRATNEGINFSKTMTEALAKKLNI

Download         Length: 387 bp

>AT226953 NZ_CP122660:c3745980-3745687 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References