226951

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 35102..35798 Replicon plasmid pS39-4-a
Accession NZ_CP088201
Organism Enterococcus faecalis strain S39-4

Toxin (Protein)


Gene name zeta Uniprot ID A0A828ZQ58
Locus tag LQ044_RS14415 Protein ID WP_002334977.1
Coordinates 35376..35798 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL01
Locus tag LQ044_RS14410 Protein ID WP_002331065.1
Coordinates 35102..35374 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ044_RS14380 (LQ044_14380) 30620..31882 + 1263 WP_000119405.1 MobV family relaxase -
LQ044_RS14385 (LQ044_14385) 32127..32603 + 477 Protein_34 protein rep -
LQ044_RS14390 (LQ044_14390) 32658..33338 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
LQ044_RS14395 (LQ044_14395) 33518..33778 + 261 Protein_36 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
LQ044_RS14400 (LQ044_14400) 33881..34777 + 897 WP_002334978.1 AAA family ATPase -
LQ044_RS14405 (LQ044_14405) 34876..35085 + 210 WP_000527318.1 peptide-binding protein -
LQ044_RS14410 (LQ044_14410) 35102..35374 + 273 WP_002331065.1 antitoxin Antitoxin
LQ044_RS14415 (LQ044_14415) 35376..35798 + 423 WP_002334977.1 zeta toxin family protein Toxin
LQ044_RS14420 (LQ044_14420) 35852..36532 + 681 WP_001015311.1 IS6-like element IS1216 family transposase -
LQ044_RS14425 (LQ044_14425) 36587..37255 - 669 Protein_42 cysteine peptidase family C39 domain-containing protein -
LQ044_RS14430 (LQ044_14430) 37426..37626 + 201 WP_002402451.1 enterocin 1071A family bacteriocin -
LQ044_RS14435 (LQ044_14435) 37648..37971 + 324 WP_002402450.1 hypothetical protein -
LQ044_RS14440 (LQ044_14440) 38169..38336 + 168 WP_002402449.1 hypothetical protein -
LQ044_RS14445 (LQ044_14445) 39182..39682 - 501 WP_010712926.1 DUF536 domain-containing protein -
LQ044_RS14450 (LQ044_14450) 39692..40072 - 381 Protein_47 initiator RepB protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid ant(6)-Ia / aph(3')-III / cat(pC221) / erm(B) / tet(L) - 1..49180 49180
- inside IScluster/Tn ant(6)-Ia / aph(3')-III / cat(pC221) / erm(B) / tet(L) - 11327..48970 37643
- inside Integron - - 1..48970 48969


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-134)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15667.64 Da        Isoelectric Point: 5.2420

>T226951 WP_002334977.1 NZ_CP088201:35376-35798 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSGSVAKF

Download         Length: 423 bp

>T226951 NZ_CP122660:2828762-2829418 [Escherichia coli]
ATGGCTTATGATTACAGCGCCAGCCTCAACCCGCAAAAAGCTCTGATCTGGCGTATCGTCCATCGGGACAATATCCCGTG
GATTCTGGATAACGGGCTGCACTGCGGCAACAGTCTGGTGCAGGCGGAAAACTGGATCAATATCGGCAACCCGGAGCTGA
TCGGCAAGCGTGCCGGGCATCCGGTACCTGTCGGAACGGGCGGGACACTGCATGACTATGTGCCGTTTTATTTTACCCCC
TTCTCGCCAATGCTGATGAACATCCACAGCGGGCGCGGCGGCATTAAGCAACGCCCCAATGAGGAGATCGTTATTCTGGT
CAGCAACTTGCGAAACGTGGCAGCACACGACGTACCCTTCGTGTTTACCGACAGCCATGCTTACTATAACTGGACCAACT
ACTACACCAGTCTGGATAGTCTGGACCAGATCGACTGGCCCATTTTGCAGGCACGGGACTTTCGCCGCGATCCAGACGAT
CCGGCTAAATTTGAACGCTATCAGGCAGAGGCGCTAATCTGGCAACACTGCCCGATCTCTCTGCTGGATGGGATAATTTG
TTACAGCGAAGAGGTCAGGTTACAATTAGAACAATGGCTGTTTCAGCGTAATCTAACAATGTCCGTTCACACACGGGCTG
GATGGTACTTCTCATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10733.17 Da        Isoelectric Point: 4.4865

>AT226951 WP_002331065.1 NZ_CP088201:35102-35374 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILNKEKVA

Download         Length: 273 bp

>AT226951 NZ_CP122660:2829415-2830482 [Escherichia coli]
ATGATCACATATACACAAGGCAATTTACTGGACGCACCGGTGGAAGCTCTGGTGAATACGGTTAATACCGTCGGTGTCAT
GGGGAAAGGCATCGCGTTGATGTTTAAAGAGCGCTTCCCCGAAAATATGAAAGTCTATGCCCTCGCCTGCAAACAAAAGC
AGGTGATCACCGGCAAAATGTTCATTACCGAAACCGGGGAACTGATGGGACCGCGCTGGATTGTTAATTTTCCGACCAAA
CAGCACTGGCGCGCTGATTCCCGCATGGAGTGGATTGAAGATGGCTTGCAGGACTTACGCCGCTTTTTGATTGAAGAGAA
CGTGCAGTCCATCGCCATTCCACCACTGGGCGCAGGCAACGGTGGTTTGAACTGGCCGGACGTTCGGGCGCAGATTGAAT
CTGCCCTTGGCGACCTTCAGGACGTTGATATCCTGATTTACCAACCGACTGAAAAATACCAGAACGTTGCCAAAAGCACT
GGCGTAAAAAAGCTCACTCCCGCCAGAGCCGCCATCGCTGAACTGGTGCGTCGCTACTGGGTATTGGGGATGGAGTGCAG
CCTACTGGAAATCCAGAAACTGGCCTGGCTGTTACAACGCGCCATTGAGCAGCATCAACAGGACGATATCCTCAAACTGC
GGTTTGAAGCTCACTATTATGGCCCCTATGCGCCCAATCTGAACCATCTGCTTAATGCGCTGGACGGCACCTATCTTAAA
GCCGAGAAACGCATCCCGGACAGCCAACCGCTGGATGTGATCTGGTTTAACGATCAGAAAAAAGAACACGTTAATGCGTA
TCTGAACAACGAAGCCAGAGAGTGGCTACCTGCGCTGGAGCAGGTCAGCCAGTTAATTGACGGCTTTGAATCGCCGTTTG
GTCTGGAGTTGCTGGCAACCGTAGACTGGTTGCTGAGCCGTGGCGAATGTCAACCAACGCTGGATTCCGTTAAGGAAGGG
CTGCACCAGTGGCCTGCGGGCGAACGCTGGGCCAGCCGTAAGTTGAGGCTGTTTGATAATAATAATCTGCAATTTGCCAT
TAACCGCGTAATGGAGTTCCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZQ58

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZL55

References