Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 480340..480911 Replicon chromosome
Accession NZ_CP088191
Organism Enterococcus faecium strain S2-6b

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag LQ050_RS02280 Protein ID WP_002286801.1
Coordinates 480570..480911 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag LQ050_RS02275 Protein ID WP_002323011.1
Coordinates 480340..480570 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ050_RS02250 (LQ050_02250) 475706..477037 + 1332 WP_002330022.1 FAD-containing oxidoreductase -
LQ050_RS02255 (LQ050_02255) 477059..477685 + 627 WP_002286816.1 cysteine hydrolase -
LQ050_RS02260 (LQ050_02260) 477868..478449 + 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
LQ050_RS02265 (LQ050_02265) 478935..479510 + 576 WP_002293673.1 SOS response-associated peptidase family protein -
LQ050_RS02270 (LQ050_02270) 479715..480053 - 339 WP_002286804.1 hypothetical protein -
LQ050_RS02275 (LQ050_02275) 480340..480570 + 231 WP_002323011.1 hypothetical protein Antitoxin
LQ050_RS02280 (LQ050_02280) 480570..480911 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LQ050_RS02285 (LQ050_02285) 481479..482641 + 1163 WP_086956687.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T226896 WP_002286801.1 NZ_CP088191:480570-480911 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

>T226896 NZ_CP122652:724186-724563 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTCCGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCTC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT226896 WP_002323011.1 NZ_CP088191:480340-480570 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp

>AT226896 NZ_CP122652:723728-724096 [Escherichia coli]
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGACGGTATCAGAGGCCGGT
TCAGAGATGTGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGGTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References