Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2100746..2101260 Replicon chromosome
Accession NZ_CP088158
Organism Staphylococcus aureus strain 697

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LRP64_RS10270 Protein ID WP_000581792.1
Coordinates 2100746..2100955 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag LRP64_RS10275 Protein ID WP_000138934.1
Coordinates 2100967..2101260 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP64_RS10250 (2096254) 2096254..2097612 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LRP64_RS10255 (2097627) 2097627..2098697 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
LRP64_RS10260 (2099015) 2099015..2100217 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LRP64_RS10265 (2100481) 2100481..2100618 - 138 WP_000828354.1 Lmo0850 family protein -
LRP64_RS10270 (2100746) 2100746..2100955 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LRP64_RS10275 (2100967) 2100967..2101260 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
LRP64_RS10280 (2101426) 2101426..2102910 + 1485 WP_057504585.1 cardiolipin synthase -
LRP64_RS10285 (2102938) 2102938..2103585 + 648 WP_001187610.1 HD domain-containing protein -
LRP64_RS10290 (2104400) 2104400..2105272 - 873 WP_000725802.1 membrane protein insertase YidC -
LRP64_RS10295 (2105358) 2105358..2105999 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T226887 WP_000581792.1 NZ_CP088158:c2100955-2100746 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T226887 NZ_CP122648:c4040635-4040237 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT226887 WP_000138934.1 NZ_CP088158:c2101260-2100967 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT226887 NZ_CP122648:c4040931-4040638 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References