226885

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1928756..1929532 Replicon chromosome
Accession NZ_CP088158
Organism Staphylococcus aureus strain 697

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LRP64_RS09300 Protein ID WP_000031108.1
Coordinates 1928756..1928908 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag LRP64_RS09305 Protein ID WP_001251218.1
Coordinates 1928933..1929532 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP64_RS09285 (1924833) 1924833..1925654 + 822 WP_000669384.1 RluA family pseudouridine synthase -
LRP64_RS09290 (1926119) 1926119..1927504 - 1386 WP_000116233.1 class II fumarate hydratase -
LRP64_RS09295 (1927700) 1927700..1928094 - 395 Protein_1823 hypothetical protein -
LRP64_RS09300 (1928756) 1928756..1928908 - 153 WP_000031108.1 SAS053 family protein Toxin
LRP64_RS09305 (1928933) 1928933..1929532 - 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
LRP64_RS09310 (1929691) 1929691..1930161 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LRP64_RS09315 (1930166) 1930166..1931293 - 1128 WP_000379977.1 tRNA epoxyqueuosine(34) reductase QueG -
LRP64_RS09320 (1931444) 1931444..1932166 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
LRP64_RS09325 (1932159) 1932159..1933616 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T226885 WP_000031108.1 NZ_CP088158:c1928908-1928756 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T226885 NZ_CP122648:3817153-3817371 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT226885 WP_001251218.1 NZ_CP088158:c1929532-1928933 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT226885 NZ_CP122648:3816753-3817127 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References