Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 864154..864686 Replicon chromosome
Accession NZ_CP088158
Organism Staphylococcus aureus strain 697

Toxin (Protein)


Gene name TscT Uniprot ID Q93CD4
Locus tag LRP64_RS04100 Protein ID WP_001103942.1
Coordinates 864366..864686 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag LRP64_RS04095 Protein ID WP_001058486.1
Coordinates 864154..864363 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP64_RS04050 (859172) 859172..860392 - 1221 WP_000266157.1 site-specific integrase -
LRP64_RS04055 (860481) 860481..861209 - 729 WP_000733774.1 staphylococcal enterotoxin type K -
LRP64_RS04060 (861233) 861233..861961 - 729 WP_001033316.1 staphylococcal enterotoxin type Q -
LRP64_RS04065 (862032) 862032..862463 - 432 WP_001228759.1 hypothetical protein -
LRP64_RS04070 (862480) 862480..862938 - 459 WP_000281657.1 ImmA/IrrE family metallo-endopeptidase -
LRP64_RS04075 (862950) 862950..863282 - 333 WP_001260004.1 helix-turn-helix transcriptional regulator -
LRP64_RS04080 (863475) 863475..863738 + 264 WP_000243851.1 helix-turn-helix transcriptional regulator -
LRP64_RS04085 (863731) 863731..864003 + 273 WP_000091731.1 helix-turn-helix domain-containing protein -
LRP64_RS04090 (864015) 864015..864161 + 147 WP_000784875.1 hypothetical protein -
LRP64_RS04095 (864154) 864154..864363 + 210 WP_001058486.1 hypothetical protein Antitoxin
LRP64_RS04100 (864366) 864366..864686 + 321 WP_001103942.1 DUF1474 family protein Toxin
LRP64_RS04105 (864750) 864750..865619 + 870 WP_001002732.1 primase alpha helix C-terminal domain-containing protein -
LRP64_RS04110 (865636) 865636..867105 + 1470 WP_000390454.1 virulence-associated E family protein -
LRP64_RS04115 (867391) 867391..867753 + 363 WP_001039168.1 hypothetical protein -
LRP64_RS04120 (867755) 867755..868039 + 285 WP_240696975.1 pathogenicity island protein -
LRP64_RS04125 (868036) 868036..868677 + 642 WP_001019764.1 hypothetical protein -
LRP64_RS04130 (869194) 869194..869535 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 855931..874486 18555


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12694.22 Da        Isoelectric Point: 4.7419

>T226881 WP_001103942.1 NZ_CP088158:864366-864686 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Download         Length: 321 bp

>T226881 NZ_CP122648:2907096-2907203 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTTGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT226881 WP_001058486.1 NZ_CP088158:864154-864363 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT226881 NZ_CP122648:c2907049-2906983 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q93CD4

Antitoxin

Source ID Structure

References