Detailed information of TA system TA226880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 846457..846934
• Replicon: chromosome
• Accession: NZ_CP088158
• Organism: Staphylococcus aureus strain 697

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: LRP64_RS03955
• Protein ID: WP_000052076.1
• Coordinates: 846457..846645 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: LRP64_RS03960
• Protein ID: WP_001059690.1
• Coordinates: 846674..846934 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRP64_RS03920 (842142)	842142..842342	+	201	WP_001059082.1	cold-shock protein	-
LRP64_RS03925 (842841)	842841..843059	-	219	WP_000005888.1	hypothetical protein	-
LRP64_RS03930 (843121)	843121..843405	-	285	WP_001004397.1	hypothetical protein	-
LRP64_RS03935 (843493)	843493..843807	-	315	Protein_762	hypothetical protein	-
LRP64_RS03940 (843900)	843900..845192	+	1293	WP_000777467.1	IS21 family transposase	-
LRP64_RS03945 (845185)	845185..845946	+	762	WP_001066124.1	IS21-like element helper ATPase IstB	-
LRP64_RS03950 (846006)	846006..846269	-	264	Protein_765	hypothetical protein	-
LRP64_RS03955 (846457)	846457..846645	-	189	WP_000052076.1	hypothetical protein	Toxin
LRP64_RS03960 (846674)	846674..846934	-	261	WP_001059690.1	hypothetical protein	Antitoxin
LRP64_RS03965 (847275)	847275..847478	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
LRP64_RS03970 (847475)	847475..847711	-	237	WP_000368687.1	hypothetical protein	-
LRP64_RS03975 (847936)	847936..848517	+	582	WP_001140697.1	histidine phosphatase family protein	-
LRP64_RS03980 (848590)	848590..849207	-	618	WP_000255554.1	LysE/ArgO family amino acid transporter	-
LRP64_RS03985 (849363)	849363..849857	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
LRP64_RS03990 (850256)	850256..850678	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
LRP64_RS03995 (850826)	850826..851542	+	717	WP_000150029.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	845182..845946	764

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (88-134)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T226880 WP_000052076.1 NZ_CP088158:c846645-846457 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T226880 NZ_CP088158:c846645-846457 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT226880 WP_001059690.1 NZ_CP088158:c846934-846674 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT226880 NZ_CP088158:c846934-846674 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56