Detailed information of TA system TA226868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1956217..1956990
• Replicon: chromosome
• Accession: NZ_CP088157
• Organism: Staphylococcus aureus strain 199

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: LQK05_RS09610
• Protein ID: WP_000031107.1
• Coordinates: 1956217..1956366 (-)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: LQK05_RS09615
• Protein ID: WP_001251224.1
• Coordinates: 1956391..1956990 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQK05_RS09595 (1952406)	1952406..1953227	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
LQK05_RS09600 (1953690)	1953690..1955075	-	1386	WP_000116234.1	class II fumarate hydratase	-
LQK05_RS09605 (1955271)	1955271..1955666	-	396	WP_000901023.1	hypothetical protein	-
LQK05_RS09610 (1956217)	1956217..1956366	-	150	WP_000031107.1	SAS053 family protein	Toxin
LQK05_RS09615 (1956391)	1956391..1956990	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
LQK05_RS09620 (1957149)	1957149..1957619	-	471	WP_000181392.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LQK05_RS09625 (1957624)	1957624..1958751	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
LQK05_RS09630 (1958902)	1958902..1959624	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
LQK05_RS09635 (1959617)	1959617..1961074	-	1458	WP_000649908.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5808.15 Da
• Isoelectric Point: 3.8962

>T226868 WP_000031107.1 NZ_CP088157:c1956366-1956217 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDS

Nucleotide

• Length: 150 bp

>T226868 NZ_CP122643:c4735724-4735338 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCCGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT226868 WP_001251224.1 NZ_CP088157:c1956990-1956391 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT226868 NZ_CP122643:c4736263-4735754 [Escherichia coli]
ATGGCATATCTGAAATTGATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGTATTG
GTGACTACTGGTACAACCTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAGTTGAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATT
TGATCTCGCAAACATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA

Structures

Antitoxin

• AlphaFold DB: W8U4V4