Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 6591147..6591781 Replicon chromosome
Accession NZ_CP088151
Organism Mesorhizobium mediterraneum strain R31

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LRP31_RS32050 Protein ID WP_095483519.1
Coordinates 6591147..6591539 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LRP31_RS32055 Protein ID WP_095483518.1
Coordinates 6591539..6591781 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP31_RS32030 (LRP31_31895) 6586608..6587780 - 1173 WP_095483523.1 glycosyltransferase family 4 protein -
LRP31_RS32035 (LRP31_31900) 6587955..6588953 + 999 WP_095483522.1 glycosyltransferase -
LRP31_RS32040 (LRP31_31905) 6588922..6590241 + 1320 WP_095483521.1 O-antigen ligase -
LRP31_RS32045 (LRP31_31910) 6590316..6591131 + 816 WP_095483520.1 pyrroline-5-carboxylate reductase -
LRP31_RS32050 (LRP31_31915) 6591147..6591539 - 393 WP_095483519.1 type II toxin-antitoxin system VapC family toxin Toxin
LRP31_RS32055 (LRP31_31920) 6591539..6591781 - 243 WP_095483518.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LRP31_RS32060 (LRP31_31925) 6591886..6593199 - 1314 WP_095483517.1 NAD(P)H-dependent oxidoreductase -
LRP31_RS32065 (LRP31_31930) 6593551..6594177 - 627 WP_095483516.1 porin family protein -
LRP31_RS32070 (LRP31_31935) 6594534..6595535 + 1002 WP_095483515.1 YihY/virulence factor BrkB family protein -
LRP31_RS32075 (LRP31_31940) 6595492..6595776 - 285 WP_095483514.1 DUF3606 domain-containing protein -
LRP31_RS32080 (LRP31_31945) 6595997..6596260 + 264 WP_029348484.1 hypothetical protein -
LRP31_RS32085 (LRP31_31950) 6596452..6596652 + 201 WP_095483513.1 CsbD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-128)

Antitoxin

Antitoxin VapB-like

(1-78)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13634.44 Da        Isoelectric Point: 4.2173

>T226856 WP_095483519.1 NZ_CP088151:c6591539-6591147 [Mesorhizobium mediterraneum]
MFVDTSVVVAILSGEEDAGEWSNRIEAAPARITSALVVLEAAMRLSTMLAVQPVVAGDAIEAFLREAEIEIVPIDAGDAA
LAIQAFSDYGKGRGHPAQLNLADCLSYACAKSHGSALLYKGNDFSHTDLA

Download         Length: 393 bp

>T226856 NZ_CP122643:2587982-2589304 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCTGTATTTAACTTCTTCGATAACCTGCTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGATAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAACAGCTCACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATCATGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8929.21 Da        Isoelectric Point: 8.7677

>AT226856 WP_095483518.1 NZ_CP088151:c6591781-6591539 [Mesorhizobium mediterraneum]
MNLQIRDPRARELARELAAKRKISMTEAVIEALESELKRESGRIPLAERLAAIANDFKAKAGQGGRAVNKDEIDEMWGHS

Download         Length: 243 bp

>AT226856 NZ_CP122643:2587716-2587982 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References