Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 3421646..3422403 Replicon chromosome
Accession NZ_CP088151
Organism Mesorhizobium mediterraneum strain R31

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag LRP31_RS16745 Protein ID WP_095482921.1
Coordinates 3421927..3422403 (+) Length 159 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag LRP31_RS16740 Protein ID WP_095482922.1
Coordinates 3421646..3421927 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP31_RS16710 (LRP31_16655) 3417339..3417680 + 342 WP_095482948.1 metalloregulator ArsR/SmtB family transcription factor -
LRP31_RS16715 (LRP31_16660) 3417677..3418603 + 927 WP_095482926.1 SRPBCC family protein -
LRP31_RS16720 (LRP31_16665) 3418826..3419374 + 549 WP_095482925.1 dihydrofolate reductase family protein -
LRP31_RS16725 (LRP31_16670) 3419477..3419614 + 138 Protein_3312 IS5/IS1182 family transposase -
LRP31_RS16730 (LRP31_16675) 3419687..3420136 - 450 WP_006202816.1 Rrf2 family transcriptional regulator -
LRP31_RS16735 (LRP31_16680) 3420388..3421374 - 987 WP_095482923.1 sulfate ABC transporter substrate-binding protein -
LRP31_RS16740 (LRP31_16685) 3421646..3421927 + 282 WP_095482922.1 DUF1778 domain-containing protein Antitoxin
LRP31_RS16745 (LRP31_16690) 3421927..3422403 + 477 WP_095482921.1 GNAT family N-acetyltransferase Toxin
LRP31_RS16750 (LRP31_16695) 3422471..3423511 - 1041 WP_095482920.1 sulfate/molybdate ABC transporter ATP-binding protein -
LRP31_RS16755 (LRP31_16700) 3423580..3424464 - 885 WP_095482919.1 sulfate ABC transporter permease subunit CysW -
LRP31_RS16760 (LRP31_16705) 3424457..3425308 - 852 WP_095482918.1 sulfate ABC transporter permease subunit CysT -
LRP31_RS16765 (LRP31_16710) 3425341..3426369 - 1029 WP_095482917.1 sulfate ABC transporter substrate-binding protein -
LRP31_RS16770 (LRP31_16715) 3426614..3427336 - 723 WP_095482916.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-142)

Antitoxin

Vibrio phage ICP1, Orf50

(14-77)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 16874.37 Da        Isoelectric Point: 9.4585

>T226854 WP_095482921.1 NZ_CP088151:3421927-3422403 [Mesorhizobium mediterraneum]
MLSAPTPLADNHDLELFQSGTESLDQWLRRRARANQVSGASRTYVVTEGVRVVGYYCLSSGGLDLAEAPGAIRRNMPDPV
PMAVLGRLAVDASWQGKGLGAALLQDAVLRTGHAATILGIRGIFVHAISAEAKAFYEHYGFAASPKNPMTLVLSLKAR

Download         Length: 477 bp

>T226854 NZ_CP122643:2226711-2226814 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10535.02 Da        Isoelectric Point: 6.4694

>AT226854 WP_095482922.1 NZ_CP088151:3421646-3421927 [Mesorhizobium mediterraneum]
MTKTAPETHAKPVNLRIREDVRVLIDRAAKIRGKTRSDFMIDAAYRAAEDTLLDQALIKVDPESYQHYLDILDEPPSGEG
FARLMNAPKPWQG

Download         Length: 282 bp

>AT226854 NZ_CP122643:c2226852-2226581 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References