Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1153897..1154552 Replicon chromosome
Accession NZ_CP088151
Organism Mesorhizobium mediterraneum strain R31

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LRP31_RS05490 Protein ID WP_095487587.1
Coordinates 1153897..1154298 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LRP31_RS05495 Protein ID WP_095487585.1
Coordinates 1154298..1154552 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP31_RS05465 (LRP31_05460) 1149434..1149706 + 273 WP_095487597.1 usg protein -
LRP31_RS05470 (LRP31_05465) 1149879..1150913 - 1035 WP_095487595.1 aldo/keto reductase -
LRP31_RS05475 (LRP31_05470) 1150973..1152154 - 1182 WP_095487593.1 MFS transporter -
LRP31_RS05480 (LRP31_05475) 1152287..1153195 + 909 WP_095487591.1 LysR family transcriptional regulator -
LRP31_RS05485 (LRP31_05480) 1153343..1153735 - 393 WP_158302647.1 hypothetical protein -
LRP31_RS05490 (LRP31_05485) 1153897..1154298 - 402 WP_095487587.1 type II toxin-antitoxin system VapC family toxin Toxin
LRP31_RS05495 (LRP31_05490) 1154298..1154552 - 255 WP_095487585.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LRP31_RS05500 (LRP31_05495) 1154640..1155302 - 663 WP_095487583.1 YggS family pyridoxal phosphate-dependent enzyme -
LRP31_RS05505 (LRP31_05500) 1155448..1158099 + 2652 WP_095487581.1 leucine--tRNA ligase -
LRP31_RS05510 (LRP31_05505) 1158086..1158673 + 588 WP_095487579.1 LPS assembly lipoprotein LptE -
LRP31_RS05515 (LRP31_05510) 1158780..1159433 - 654 WP_095487577.1 fructose-6-phosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14800.05 Da        Isoelectric Point: 5.2241

>T226851 WP_095487587.1 NZ_CP088151:c1154298-1153897 [Mesorhizobium mediterraneum]
MYLLDTNIVSDVERRLLKPTAWLASIDPDSISLSVITIGEIERAIVKLRKVDPERGTRLDLWLRELRRDNADRILAVTEE
VALAWGRISAGRTRGSADTLIAATALVHDLILVTRNVADFNDTGVTVLNPWAI

Download         Length: 402 bp

>T226851 NZ_CP122643:1157421-1157732 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAATAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9622.77 Da        Isoelectric Point: 5.1283

>AT226851 WP_095487585.1 NZ_CP088151:c1154552-1154298 [Mesorhizobium mediterraneum]
MNWHLQDAKNNFSKVVQRARSEGPQTVTLRGERAAVVLSAEDYDRLAGKKKTLAEYLLTGPVWDDDFAEEVNRRSDTMIR
DIDL

Download         Length: 255 bp

>AT226851 NZ_CP122643:1157729-1158148 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGATACTAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAATAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References