Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5176536..5177183 Replicon chromosome
Accession NZ_CP088149
Organism Pseudomonas sp. S06B 330

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CX511_RS23345 Protein ID WP_045182275.1
Coordinates 5176767..5177183 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CX511_RS23340 Protein ID WP_045182277.1
Coordinates 5176536..5176766 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CX511_RS23320 5171977..5173275 - 1299 WP_259407434.1 precorrin-3B synthase -
CX511_RS23325 5173432..5174643 + 1212 WP_101292302.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
CX511_RS23330 5174636..5175733 + 1098 WP_101292300.1 cobalt-precorrin-5B (C(1))-methyltransferase -
CX511_RS23335 5175730..5176440 + 711 WP_045182278.1 cobalt-precorrin-6A reductase -
CX511_RS23340 5176536..5176766 + 231 WP_045182277.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CX511_RS23345 5176767..5177183 + 417 WP_045182275.1 tRNA(fMet)-specific endonuclease VapC Toxin
CX511_RS23350 5177404..5177841 + 438 WP_045182273.1 NfeD family protein -
CX511_RS23355 5177865..5178722 + 858 WP_045182271.1 SPFH domain-containing protein -
CX511_RS23360 5178843..5179229 + 387 WP_045182269.1 DUF2946 domain-containing protein -
CX511_RS23365 5179277..5179747 + 471 WP_101292298.1 copper chaperone PCu(A)C -
CX511_RS23370 5179767..5180195 + 429 WP_045182264.1 DUF2946 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15307.66 Da        Isoelectric Point: 7.9271

>T226849 WP_045182275.1 NZ_CP088149:5176767-5177183 [Pseudomonas sp. S06B 330]
MLKYMLDTNICIFTLKNKPQAIREAFNRHHGQLCISTITLMELIYGAEKSAAAERNLAVVEGFAARLEVLSYDSHAAAHS
GQLRAELARAGTPIGPYDQMIAGHARSLGLLLVTNNMREFQRVPGLRVEDWLNSSVQL

Download         Length: 417 bp

>T226849 NZ_CP122643:c832966-832589 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8480.45 Da        Isoelectric Point: 4.5702

>AT226849 WP_045182277.1 NZ_CP088149:5176536-5176766 [Pseudomonas sp. S06B 330]
MEQGAVFKSNRSQAVRLPKSVALPEDVKRVDVVAVGRTRIISPAGETWDSWFEGPSVSADFMAEREQPTDQEREGF

Download         Length: 231 bp

>AT226849 NZ_CP122643:c833424-833056 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References