Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4866578..4867113 Replicon chromosome
Accession NZ_CP088147
Organism Mesorhizobium ciceri strain R30

Toxin (Protein)


Gene name relE Uniprot ID A0A3S2GN36
Locus tag LRP29_RS23785 Protein ID WP_024504679.1
Coordinates 4866578..4866853 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E8THE0
Locus tag LRP29_RS23790 Protein ID WP_013532247.1
Coordinates 4866853..4867113 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP29_RS23760 (LRP29_23715) 4862599..4863510 - 912 WP_013532241.1 ABC transporter substrate-binding protein -
LRP29_RS23765 (LRP29_23720) 4863716..4864288 + 573 WP_013532242.1 NADPH-dependent FMN reductase -
LRP29_RS23770 (LRP29_23725) 4864297..4865508 - 1212 WP_024504678.1 MFS transporter -
LRP29_RS23775 (LRP29_23730) 4865505..4866005 - 501 WP_013532244.1 transcription antitermination factor NusB -
LRP29_RS23780 (LRP29_23735) 4866002..4866496 - 495 WP_013532245.1 6,7-dimethyl-8-ribityllumazine synthase -
LRP29_RS23785 (LRP29_23740) 4866578..4866853 - 276 WP_024504679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRP29_RS23790 (LRP29_23745) 4866853..4867113 - 261 WP_013532247.1 ribbon-helix-helix domain-containing protein Antitoxin
LRP29_RS23795 (LRP29_23750) 4867177..4867794 - 618 WP_024504680.1 riboflavin synthase -
LRP29_RS23800 (LRP29_23755) 4867807..4868922 - 1116 WP_024504681.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
LRP29_RS23805 (LRP29_23760) 4868925..4869404 - 480 WP_024504682.1 transcriptional regulator NrdR -
LRP29_RS23810 (LRP29_23765) 4869562..4870227 - 666 WP_024504683.1 hypothetical protein -
LRP29_RS23815 (LRP29_23770) 4870304..4871617 - 1314 WP_013532252.1 serine hydroxymethyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10628.25 Da        Isoelectric Point: 8.5620

>T226847 WP_024504679.1 NZ_CP088147:c4866853-4866578 [Mesorhizobium ciceri]
MELKWTNKALSDLVRLHDFLVLANGPAAARAVQSLIAAPARLVEYPRIGERLEEFEPREVRRILVGSYEIRYEIQNTTIS
VLRLWHTREDR

Download         Length: 276 bp

>T226847 NZ_CP122642:c43261-43001 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACATTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAATCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTATTTTTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9646.11 Da        Isoelectric Point: 5.6994

>AT226847 WP_013532247.1 NZ_CP088147:c4867113-4866853 [Mesorhizobium ciceri]
MDTKVITAHVPLPLAEKVDQLAARLERPRGWIVKQALSAWVDLEEERRRLTLEAMADVDAGRVIDHQAVQAWAESLGTDK
PLPVPR

Download         Length: 261 bp

>AT226847 NZ_CP122642:c43011-42760 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S2GN36

Antitoxin

Source ID Structure
AlphaFold DB A0A436MZK2

References