Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3142811..3143592 Replicon chromosome
Accession NZ_CP088147
Organism Mesorhizobium ciceri strain R30

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3S2EU37
Locus tag LRP29_RS15020 Protein ID WP_024501771.1
Coordinates 3142811..3143305 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID E8T9Q9
Locus tag LRP29_RS15025 Protein ID WP_013530564.1
Coordinates 3143302..3143592 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP29_RS14990 (LRP29_14965) 3138079..3138885 - 807 WP_013530558.1 ABC transporter substrate-binding protein -
LRP29_RS14995 (LRP29_14970) 3138996..3140159 - 1164 WP_024501776.1 saccharopine dehydrogenase family protein -
LRP29_RS15000 (LRP29_14975) 3140156..3140656 - 501 WP_024501775.1 Lrp/AsnC family transcriptional regulator -
LRP29_RS15005 (LRP29_14980) 3140788..3141660 - 873 WP_024501774.1 LysR substrate-binding domain-containing protein -
LRP29_RS15010 (LRP29_14985) 3141798..3142004 + 207 WP_024501773.1 hypothetical protein -
LRP29_RS15015 (LRP29_14990) 3142026..3142775 + 750 WP_024501772.1 sulfite exporter TauE/SafE family protein -
LRP29_RS15020 (LRP29_14995) 3142811..3143305 - 495 WP_024501771.1 GNAT family N-acetyltransferase Toxin
LRP29_RS15025 (LRP29_15000) 3143302..3143592 - 291 WP_013530564.1 DUF1778 domain-containing protein Antitoxin
LRP29_RS15030 (LRP29_15005) 3143679..3144129 - 451 Protein_2974 universal stress protein -
LRP29_RS15035 (LRP29_15010) 3144338..3144919 + 582 WP_024501770.1 histidine phosphatase family protein -
LRP29_RS15040 (LRP29_15015) 3144950..3145351 - 402 WP_013530567.1 VOC family protein -
LRP29_RS15045 (LRP29_15020) 3145472..3146224 - 753 WP_024501769.1 pseudouridine synthase -
LRP29_RS15050 (LRP29_15025) 3146223..3146828 + 606 WP_245265291.1 SRPBCC domain-containing protein -
LRP29_RS15055 (LRP29_15030) 3146870..3147712 - 843 WP_032898616.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17628.33 Da        Isoelectric Point: 9.4400

>T226843 WP_024501771.1 NZ_CP088147:c3143305-3142811 [Mesorhizobium ciceri]
VTLSVPVPLADHHELGEFSSGITALDDWLKKRARTNQAGGVSRTYVTCKGNRVIGYYAVASGAVKMVETSSRFRRNMPDP
IPVAVLGRLAVDQAYHGRGIGRALVRDAGLRILQAAEILGIKGIVVHAISDDARAFYITIGFERSPVEPLTLMVTLADLS
ESIG

Download         Length: 495 bp

>T226843 NZ_CP122639:23454-23702 [Escherichia coli]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10842.51 Da        Isoelectric Point: 9.9898

>AT226843 WP_013530564.1 NZ_CP088147:c3143592-3143302 [Mesorhizobium ciceri]
MPTSHHPVPKSVPLNIRVKPEVRNLIDRAAELLGKNRTDFMLEASQRAAEEALLNRLVFTVEPDVYAAFLARLDAPPQPN
DRLRRTMTTKAPWEAA

Download         Length: 291 bp

>AT226843 NZ_CP122639:23699-24046 [Escherichia coli]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S2EU37

Antitoxin

Source ID Structure
AlphaFold DB A0A3S2IG73

References