Detailed information of TA system TA226841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/Fic-DUF4065
• Location: 715916..716946
• Replicon: chromosome
• Accession: NZ_CP088145
• Organism: Corynebacterium diphtheriae strain SCPM-O-B-4453

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: LRM94_RS03550
• Protein ID: WP_070794874.1
• Coordinates: 715916..716335 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A806GUF5
• Locus tag: LRM94_RS03555
• Protein ID: WP_014318824.1
• Coordinates: 716380..716946 (-)
• Length: 189 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRM94_RS03535 (LRM94_03535)	712573..713427	+	855	WP_014303121.1	hypothetical protein	-
LRM94_RS03540 (LRM94_03540)	713420..714328	-	909	WP_014309246.1	DUF1906 domain-containing protein	-
LRM94_RS03545 (LRM94_03545)	714457..715656	-	1200	WP_014318823.1	cation:proton antiporter	-
LRM94_RS03550 (LRM94_03550)	715916..716335	-	420	WP_070794874.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
LRM94_RS03555 (LRM94_03555)	716380..716946	-	567	WP_014318824.1	Panacea domain-containing protein	Antitoxin
LRM94_RS03560 (LRM94_03560)	717279..717554	+	276	WP_014309249.1	hypothetical protein	-
LRM94_RS03570 (LRM94_03570)	718226..718501	+	276	WP_014301596.1	hypothetical protein	-
LRM94_RS03575 (LRM94_03575)	718508..719260	+	753	WP_014318826.1	precorrin-6A synthase (deacetylating)	-
LRM94_RS03580 (LRM94_03580)	719279..719536	-	258	WP_010934589.1	mycoredoxin	-
LRM94_RS03585 (LRM94_03585)	719557..720060	-	504	WP_014303129.1	dihydrofolate reductase	-
LRM94_RS03590 (LRM94_03590)	720060..720872	-	813	WP_014318827.1	thymidylate synthase	-
LRM94_RS03595 (LRM94_03595)	720966..721724	-	759	WP_014318828.1	3'(2'),5'-bisphosphate nucleotidase CysQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	715916..726577	10661

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (11-93)

Antitoxin

• Antitoxin SocA-like, Panacea domain (23-116)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15477.61 Da
• Isoelectric Point: 8.2756

>T226841 WP_070794874.1 NZ_CP088145:c716335-715916 [Corynebacterium diphtheriae]
MVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Nucleotide

• Length: 420 bp

>T226841 NZ_CP122638:54159-54446 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAACTGGACAAGGCTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGTGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGCGAAAGAATGAGATAA

Antitoxin

Protein

• Length: 189 a.a.
• Molecular weight: 21053.55 Da
• Isoelectric Point: 4.5592

>AT226841 WP_014318824.1 NZ_CP088145:c716946-716380 [Corynebacterium diphtheriae]
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDSLEQAADDVAAENAETLRLLAFI

Nucleotide

• Length: 567 bp

>AT226841 NZ_CP122638:53911-54162 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAACCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TTGATGCCCTAGACGATCAGGAGTTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGATCTGGAT
AAATACCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A806GUF5