Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4163953..4164734 Replicon chromosome
Accession NZ_CP088142
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4548

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LRM93_RS20310 Protein ID WP_000626100.1
Coordinates 4163953..4164444 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LRM93_RS20315 Protein ID WP_001110452.1
Coordinates 4164441..4164734 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM93_RS20275 (4159424) 4159424..4159771 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
LRM93_RS20280 (4159747) 4159747..4161450 + 1704 WP_000068887.1 protein-disulfide reductase DsbD -
LRM93_RS20285 (4161487) 4161487..4162062 + 576 WP_001188509.1 transcriptional regulator -
LRM93_RS20295 (4162333) 4162333..4162407 - 75 Protein_3973 helix-turn-helix domain-containing protein -
LRM93_RS20300 (4162787) 4162787..4162864 + 78 Protein_3974 porin family protein -
LRM93_RS20305 (4162964) 4162964..4163705 + 742 Protein_3975 non-specific acid phosphatase -
LRM93_RS20310 (4163953) 4163953..4164444 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LRM93_RS20315 (4164441) 4164441..4164734 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LRM93_RS20320 (4165051) 4165051..4165272 + 222 WP_001576552.1 hypothetical protein -
LRM93_RS20325 (4165538) 4165538..4166413 + 876 WP_000921676.1 AraC family transcriptional regulator -
LRM93_RS20330 (4166410) 4166410..4166697 + 288 WP_077906904.1 transcriptional regulator RtsB -
LRM93_RS20335 (4166690) 4166690..4166998 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
LRM93_RS20340 (4166997) 4166997..4167245 + 249 Protein_3982 Ig-like domain-containing protein -
LRM93_RS20345 (4167357) 4167357..4167488 + 132 Protein_3983 hypothetical protein -
LRM93_RS20350 (4167782) 4167782..4168687 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T226834 WP_000626100.1 NZ_CP088142:c4164444-4163953 [Salmonella enterica subsp. enterica serovar Gallinarum]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T226834 NZ_CP122634:3968935-3969153 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT226834 WP_001110452.1 NZ_CP088142:c4164734-4164441 [Salmonella enterica subsp. enterica serovar Gallinarum]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT226834 NZ_CP122634:3968535-3968909 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References