Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4015943..4016493 Replicon chromosome
Accession NZ_CP088142
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4548

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LRM93_RS19525 Protein ID WP_001199743.1
Coordinates 4015943..4016251 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LRM93_RS19530 Protein ID WP_001118105.1
Coordinates 4016254..4016493 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM93_RS23240 (4011479) 4011479..4012501 - 1023 WP_250645138.1 fimbria/pilus outer membrane usher protein -
LRM93_RS19505 (4012518) 4012518..4013258 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
LRM93_RS19510 (4013380) 4013380..4013910 - 531 WP_232520924.1 SEF14 fimbria major subunit SefA -
LRM93_RS19515 (4014232) 4014232..4015365 + 1134 Protein_3823 IS3 family transposase -
LRM93_RS19520 (4015397) 4015397..4015537 - 141 Protein_3824 Arm DNA-binding domain-containing protein -
LRM93_RS19525 (4015943) 4015943..4016251 - 309 WP_001199743.1 CcdB family protein Toxin
LRM93_RS19530 (4016254) 4016254..4016493 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LRM93_RS19535 (4016602) 4016602..4016850 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LRM93_RS19540 (4017041) 4017041..4017472 - 432 Protein_3828 helix-turn-helix domain-containing protein -
LRM93_RS19550 (4018229) 4018229..4019248 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LRM93_RS19555 (4019276) 4019276..4019806 - 531 WP_000896758.1 gluconokinase -
LRM93_RS19560 (4020023) 4020023..4021054 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4014324..4017427 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T226832 WP_001199743.1 NZ_CP088142:c4016251-4015943 [Salmonella enterica subsp. enterica serovar Gallinarum]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T226832 NZ_CP122634:2989244-2989351 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT226832 WP_001118105.1 NZ_CP088142:c4016493-4016254 [Salmonella enterica subsp. enterica serovar Gallinarum]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT226832 NZ_CP122634:c2989197-2989131 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References