Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3965698..3966274 Replicon chromosome
Accession NZ_CP088142
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4548

Toxin (Protein)


Gene name shpA Uniprot ID A0A5Y3LBV7
Locus tag LRM93_RS19295 Protein ID WP_024136220.1
Coordinates 3965987..3966274 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LRM93_RS19290 Protein ID WP_000063142.1
Coordinates 3965698..3966000 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM93_RS19275 (3962208) 3962208..3964358 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
LRM93_RS19280 (3964453) 3964453..3964656 + 204 WP_000460616.1 YbdD/YjiX family protein -
LRM93_RS19285 (3964667) 3964667..3965623 + 957 WP_000187843.1 GTPase -
LRM93_RS19290 (3965698) 3965698..3966000 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LRM93_RS19295 (3965987) 3965987..3966274 - 288 WP_024136220.1 BrnT family toxin Toxin
LRM93_RS19300 (3966691) 3966691..3968532 + 1842 WP_000974636.1 nuclease-related domain-containing DEAD/DEAH box helicase -
LRM93_RS19305 (3969145) 3969145..3969720 + 576 WP_000593784.1 restriction endonuclease subunit S -
LRM93_RS19310 (3969725) 3969725..3970978 + 1254 WP_001206754.1 N-6 DNA methylase -
LRM93_RS23230 (3971010) 3971010..3971144 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11232.76 Da        Isoelectric Point: 9.9856

>T226831 WP_024136220.1 NZ_CP088142:c3966274-3965987 [Salmonella enterica subsp. enterica serovar Gallinarum]
IPMEFEWDANKAKSNLRKHGVRFEDAVLVFDAPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T226831 NZ_CP122634:2988709-2988816 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT226831 WP_000063142.1 NZ_CP088142:c3966000-3965698 [Salmonella enterica subsp. enterica serovar Gallinarum]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT226831 NZ_CP122634:c2988662-2988596 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCTGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y3LBV7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References