Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3390492..3391112 Replicon chromosome
Accession NZ_CP088142
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4548

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LRM93_RS16655 Protein ID WP_001280991.1
Coordinates 3390894..3391112 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LRM93_RS16650 Protein ID WP_000344807.1
Coordinates 3390492..3390866 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM93_RS16640 (3385631) 3385631..3386824 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LRM93_RS16645 (3386847) 3386847..3389996 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LRM93_RS16650 (3390492) 3390492..3390866 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LRM93_RS16655 (3390894) 3390894..3391112 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LRM93_RS16660 (3391291) 3391291..3391842 + 552 WP_001278793.1 maltose O-acetyltransferase -
LRM93_RS16665 (3391960) 3391960..3392430 + 471 WP_000136183.1 YlaC family protein -
LRM93_RS16670 (3392486) 3392486..3392626 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LRM93_RS16675 (3392632) 3392632..3392892 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LRM93_RS16680 (3393117) 3393117..3394667 + 1551 WP_000213140.1 EAL domain-containing protein -
LRM93_RS16690 (3394898) 3394898..3395287 + 390 WP_000961287.1 MGMT family protein -
LRM93_RS16695 (3395320) 3395320..3395889 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T226827 WP_001280991.1 NZ_CP088142:3390894-3391112 [Salmonella enterica subsp. enterica serovar Gallinarum]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T226827 NZ_CP122634:2211126-2211229 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT226827 WP_000344807.1 NZ_CP088142:3390492-3390866 [Salmonella enterica subsp. enterica serovar Gallinarum]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT226827 NZ_CP122634:c2211230-2210996 [Escherichia coli]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTAGTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References