Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 835874..836499 Replicon chromosome
Accession NZ_CP088142
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4548

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LRM93_RS04035 Protein ID WP_000911335.1
Coordinates 836101..836499 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LRM93_RS04030 Protein ID WP_000557549.1
Coordinates 835874..836101 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM93_RS04000 (830882) 830882..832399 + 1518 WP_000003339.1 lysine--tRNA ligase -
LRM93_RS04005 (832475) 832475..833020 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LRM93_RS04010 (833285) 833285..834043 + 759 WP_000244328.1 amidase activator ActS -
LRM93_RS04020 (834328) 834328..835134 - 807 WP_077906915.1 DUF1460 domain-containing protein -
LRM93_RS04025 (835414) 835414..835665 - 252 WP_001576352.1 hypothetical protein -
LRM93_RS04030 (835874) 835874..836101 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LRM93_RS04035 (836101) 836101..836499 + 399 WP_000911335.1 tRNA(fMet)-specific endonuclease VapC Toxin
LRM93_RS04040 (837307) 837307..837843 + 537 WP_001038501.1 STM3031 family outer membrane protein -
LRM93_RS04045 (837890) 837890..838522 + 633 WP_000835263.1 YfdX family protein -
LRM93_RS04050 (839241) 839241..839822 + 582 WP_001244651.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 835414..845683 10269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14910.24 Da        Isoelectric Point: 7.2155

>T226817 WP_000911335.1 NZ_CP088142:836101-836499 [Salmonella enterica subsp. enterica serovar Gallinarum]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVAVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T226817 NZ_CP122633:128169-128318 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT226817 WP_000557549.1 NZ_CP088142:835874-836101 [Salmonella enterica subsp. enterica serovar Gallinarum]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT226817 NZ_CP122633:c128125-128064 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References