Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 200104..200864 Replicon chromosome
Accession NZ_CP088142
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4548

Toxin (Protein)


Gene name tacT Uniprot ID A0A5Y3L7G9
Locus tag LRM93_RS00930 Protein ID WP_000533913.1
Coordinates 200379..200864 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LRM93_RS00925 Protein ID WP_000965886.1
Coordinates 200104..200391 (+) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM93_RS00905 (195509) 195509..196420 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
LRM93_RS00910 (196430) 196430..198499 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LRM93_RS00915 (198889) 198889..199287 + 399 Protein_182 IS3 family transposase -
LRM93_RS00920 (199459) 199459..199926 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
LRM93_RS00925 (200104) 200104..200391 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LRM93_RS00930 (200379) 200379..200864 + 486 WP_000533913.1 GNAT family N-acetyltransferase Toxin
LRM93_RS00935 (201235) 201235..201774 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LRM93_RS00940 (201948) 201948..202160 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LRM93_RS00945 (202448) 202448..202738 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LRM93_RS00950 (203177) 203177..203887 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LRM93_RS00955 (203937) 203937..204911 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LRM93_RS00960 (205130) 205130..205792 - 663 WP_000747545.1 OmpA family lipoprotein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(31-152)

Antitoxin

(5-94)


Sequences


Toxin        


Download         Length: 162 a.a.        Molecular weight: 17775.50 Da        Isoelectric Point: 10.0983

>T226814 WP_000533913.1 NZ_CP088142:200379-200864 [Salmonella enterica subsp. enterica serovar Gallinarum]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRFYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T226814 NZ_CP122633:c14675-14259 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT226814 WP_000965886.1 NZ_CP088142:200104-200391 [Salmonella enterica subsp. enterica serovar Gallinarum]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT226814 NZ_CP122633:c14902-14672 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5Y3L7G9


Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References