Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 200104..200864 | Replicon | chromosome |
Accession | NZ_CP088142 | ||
Organism | Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4548 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | A0A5Y3L7G9 |
Locus tag | LRM93_RS00930 | Protein ID | WP_000533913.1 |
Coordinates | 200379..200864 (+) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | M7RHS4 |
Locus tag | LRM93_RS00925 | Protein ID | WP_000965886.1 |
Coordinates | 200104..200391 (+) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LRM93_RS00905 (195509) | 195509..196420 | + | 912 | WP_001168551.1 | glycine--tRNA ligase subunit alpha | - |
LRM93_RS00910 (196430) | 196430..198499 | + | 2070 | WP_001291741.1 | glycine--tRNA ligase subunit beta | - |
LRM93_RS00915 (198889) | 198889..199287 | + | 399 | Protein_182 | IS3 family transposase | - |
LRM93_RS00920 (199459) | 199459..199926 | + | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
LRM93_RS00925 (200104) | 200104..200391 | + | 288 | WP_000965886.1 | DUF1778 domain-containing protein | Antitoxin |
LRM93_RS00930 (200379) | 200379..200864 | + | 486 | WP_000533913.1 | GNAT family N-acetyltransferase | Toxin |
LRM93_RS00935 (201235) | 201235..201774 | - | 540 | WP_000047147.1 | copper-binding periplasmic metallochaperone CueP | - |
LRM93_RS00940 (201948) | 201948..202160 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
LRM93_RS00945 (202448) | 202448..202738 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
LRM93_RS00950 (203177) | 203177..203887 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
LRM93_RS00955 (203937) | 203937..204911 | - | 975 | WP_000804678.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
LRM93_RS00960 (205130) | 205130..205792 | - | 663 | WP_000747545.1 | OmpA family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17775.50 Da Isoelectric Point: 10.0983
>T226814 WP_000533913.1 NZ_CP088142:200379-200864 [Salmonella enterica subsp. enterica serovar Gallinarum]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRFYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRFYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
>T226814 NZ_CP122633:c14675-14259 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT226814 WP_000965886.1 NZ_CP088142:200104-200391 [Salmonella enterica subsp. enterica serovar Gallinarum]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
>AT226814 NZ_CP122633:c14902-14672 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5Y3L7G9 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 7AK8 | |
AlphaFold DB | A0A3V2JDX2 |