Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4249945..4250461 Replicon chromosome
Accession NZ_CP088138
Organism Salmonella enterica subsp. enterica serovar Hissar strain SCPM-O-B-4549

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LRM92_RS20835 Protein ID WP_000220578.1
Coordinates 4249945..4250229 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LRM92_RS20840 Protein ID WP_000212724.1
Coordinates 4250219..4250461 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM92_RS20820 (4245161) 4245161..4246809 + 1649 Protein_4077 alpha,alpha-phosphotrehalase -
LRM92_RS20825 (4247218) 4247218..4249356 + 2139 WP_000187817.1 anaerobic ribonucleoside-triphosphate reductase -
LRM92_RS20830 (4249477) 4249477..4249941 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRM92_RS20835 (4249945) 4249945..4250229 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRM92_RS20840 (4250219) 4250219..4250461 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRM92_RS20845 (4250539) 4250539..4252452 - 1914 WP_001212137.1 BglG family transcription antiterminator -
LRM92_RS20850 (4252469) 4252469..4253209 - 741 WP_000779263.1 KDGP aldolase family protein -
LRM92_RS20855 (4253206) 4253206..4254324 - 1119 WP_001139187.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LRM92_RS20860 (4254308) 4254308..4255441 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T226808 WP_000220578.1 NZ_CP088138:c4250229-4249945 [Salmonella enterica subsp. enterica serovar Hissar]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T226808 NZ_CP122629:3959726-3960004 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT226808 WP_000212724.1 NZ_CP088138:c4250461-4250219 [Salmonella enterica subsp. enterica serovar Hissar]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT226808 NZ_CP122629:3959463-3959723 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References