226803

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3515196..3515816 Replicon chromosome
Accession NZ_CP088138
Organism Salmonella enterica subsp. enterica serovar Hissar strain SCPM-O-B-4549

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LRM92_RS17350 Protein ID WP_001280991.1
Coordinates 3515598..3515816 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LRM92_RS17345 Protein ID WP_156038034.1
Coordinates 3515196..3515570 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM92_RS17335 (3510335) 3510335..3511528 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LRM92_RS17340 (3511551) 3511551..3514700 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LRM92_RS17345 (3515196) 3515196..3515570 + 375 WP_156038034.1 Hha toxicity modulator TomB Antitoxin
LRM92_RS17350 (3515598) 3515598..3515816 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LRM92_RS17355 (3515995) 3515995..3516546 + 552 WP_001278792.1 maltose O-acetyltransferase -
LRM92_RS17360 (3516663) 3516663..3517133 + 471 WP_000136181.1 YlaC family protein -
LRM92_RS17365 (3517189) 3517189..3517329 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LRM92_RS17370 (3517335) 3517335..3517595 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LRM92_RS17375 (3517820) 3517820..3519370 + 1551 WP_000213139.1 EAL domain-containing protein -
LRM92_RS17385 (3519601) 3519601..3519990 + 390 WP_000961285.1 MGMT family protein -
LRM92_RS17390 (3520023) 3520023..3520592 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T226803 WP_001280991.1 NZ_CP088138:3515598-3515816 [Salmonella enterica subsp. enterica serovar Hissar]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T226803 NZ_CP122629:2803282-2803389 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14511.31 Da        Isoelectric Point: 4.8886

>AT226803 WP_156038034.1 NZ_CP088138:3515196-3515570 [Salmonella enterica subsp. enterica serovar Hissar]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHDWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT226803 NZ_CP122629:c2803229-2803168 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure

References