Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870157..870817 Replicon chromosome
Accession NZ_CP088138
Organism Salmonella enterica subsp. enterica serovar Hissar strain SCPM-O-B-4549

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LRM92_RS04245 Protein ID WP_000244756.1
Coordinates 870404..870817 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LRM92_RS04240 Protein ID WP_000351186.1
Coordinates 870157..870423 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM92_RS04220 (866085) 866085..867518 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
LRM92_RS04225 (867677) 867677..867988 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LRM92_RS04230 (868152) 868152..868811 + 660 WP_000250289.1 hemolysin III family protein -
LRM92_RS04235 (868927) 868927..869907 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
LRM92_RS04240 (870157) 870157..870423 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LRM92_RS04245 (870404) 870404..870817 + 414 WP_000244756.1 protein YgfX Toxin
LRM92_RS04250 (870870) 870870..871391 - 522 WP_001055885.1 flavodoxin FldB -
LRM92_RS04255 (871504) 871504..872400 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LRM92_RS04260 (872424) 872424..873137 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRM92_RS04265 (873143) 873143..874876 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T226791 WP_000244756.1 NZ_CP088138:870404-870817 [Salmonella enterica subsp. enterica serovar Hissar]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T226791 NZ_CP122629:268103-268378 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT226791 WP_000351186.1 NZ_CP088138:870157-870423 [Salmonella enterica subsp. enterica serovar Hissar]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT226791 NZ_CP122629:268375-268734 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References