Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 13116..13641 | Replicon | plasmid pB-4515_1 |
| Accession | NZ_CP088137 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SCPM-O-B-4515 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | LRM91_RS22550 | Protein ID | WP_001159863.1 |
| Coordinates | 13336..13641 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | LRM91_RS22545 | Protein ID | WP_000813641.1 |
| Coordinates | 13116..13334 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRM91_RS22510 (LRM91_22510) | 8143..8856 | + | 714 | WP_000801114.1 | hypothetical protein | - |
| LRM91_RS22515 (LRM91_22515) | 8981..9565 | + | 585 | WP_024134326.1 | hypothetical protein | - |
| LRM91_RS22520 (LRM91_22520) | 9638..9850 | + | 213 | WP_000063791.1 | FaeA/PapI family transcriptional regulator | - |
| LRM91_RS22525 (LRM91_22525) | 10111..10272 | + | 162 | WP_001816720.1 | hypothetical protein | - |
| LRM91_RS22530 (LRM91_22530) | 10298..11146 | + | 849 | WP_249895818.1 | SdiA-regulated domain-containing protein | - |
| LRM91_RS22535 (LRM91_22535) | 11716..12144 | - | 429 | WP_001746752.1 | type II toxin-antitoxin system VapC family toxin | - |
| LRM91_RS22540 (LRM91_22540) | 12141..12371 | - | 231 | WP_001261283.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| LRM91_RS22545 (LRM91_22545) | 13116..13334 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| LRM91_RS22550 (LRM91_22550) | 13336..13641 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| LRM91_RS22555 (LRM91_22555) | 13643..13933 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| LRM91_RS22560 (LRM91_22560) | 13930..14451 | + | 522 | WP_249895819.1 | cytoplasmic protein | - |
| LRM91_RS22565 (LRM91_22565) | 14486..15268 | + | 783 | WP_249895820.1 | site-specific integrase | - |
| LRM91_RS22570 (LRM91_22570) | 15277..15828 | + | 552 | WP_000545754.1 | EAL domain-containing protein | - |
| LRM91_RS22575 (LRM91_22575) | 16015..16503 | + | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| LRM91_RS22580 (LRM91_22580) | 16497..16982 | + | 486 | WP_000905606.1 | membrane protein | - |
| LRM91_RS22585 (LRM91_22585) | 17259..17546 | - | 288 | WP_071530243.1 | hypothetical protein | - |
| LRM91_RS22590 (LRM91_22590) | 17702..18262 | + | 561 | WP_071785580.1 | inverse autotransporter beta domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | faeH / faeI / fdeC / spvC / spvB | 1..86811 | 86811 | |
| - | flank | IS/Tn | - | - | 18329..18679 | 350 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T226787 WP_001159863.1 NZ_CP088137:13336-13641 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T226787 NZ_CP122625:c4257903-4257730 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT226787 WP_000813641.1 NZ_CP088137:13116-13334 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT226787 NZ_CP122625:c4258227-4257931 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |