Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 1449232..1449782 | Replicon | chromosome |
| Accession | NZ_CP088136 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SCPM-O-B-4515 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | M7RJ32 |
| Locus tag | LRM91_RS06895 | Protein ID | WP_001199743.1 |
| Coordinates | 1449474..1449782 (+) | Length | 103 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | - |
| Locus tag | LRM91_RS06890 | Protein ID | WP_249895581.1 |
| Coordinates | 1449232..1449471 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRM91_RS06855 (1444671) | 1444671..1445702 | - | 1032 | WP_000453347.1 | L-idonate 5-dehydrogenase | - |
| LRM91_RS06860 (1445919) | 1445919..1446449 | + | 531 | WP_000896758.1 | gluconokinase | - |
| LRM91_RS06865 (1446477) | 1446477..1447496 | - | 1020 | WP_000152558.1 | NAD(P)-dependent alcohol dehydrogenase | - |
| LRM91_RS06875 (1448253) | 1448253..1448684 | + | 432 | Protein_1343 | helix-turn-helix domain-containing protein | - |
| LRM91_RS06880 (1448715) | 1448715..1448798 | + | 84 | WP_228958541.1 | DUF4942 domain-containing protein | - |
| LRM91_RS06885 (1448875) | 1448875..1449123 | + | 249 | WP_000168388.1 | ribbon-helix-helix domain-containing protein | - |
| LRM91_RS06890 (1449232) | 1449232..1449471 | + | 240 | WP_249895581.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| LRM91_RS06895 (1449474) | 1449474..1449782 | + | 309 | WP_001199743.1 | CcdB family protein | Toxin |
| LRM91_RS06900 (1450188) | 1450188..1450328 | + | 141 | Protein_1348 | Arm DNA-binding domain-containing protein | - |
| LRM91_RS06905 (1450360) | 1450360..1451491 | - | 1132 | Protein_1349 | IS3 family transposase | - |
| LRM91_RS06910 (1451813) | 1451813..1452343 | + | 531 | WP_000909461.1 | SEF14 fimbria major subunit SefA | - |
| LRM91_RS06915 (1452465) | 1452465..1453205 | + | 741 | WP_249895582.1 | SEF14/SEF18 fimbria chaperone SefB | - |
| LRM91_RS23010 (1453222) | 1453222..1454103 | + | 882 | WP_283939292.1 | fimbria/pilus outer membrane usher protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 1448298..1451399 | 3101 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11845.67 Da Isoelectric Point: 6.7228
>T226771 WP_001199743.1 NZ_CP088136:1449474-1449782 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF
Download Length: 309 bp
>T226771 NZ_CP122625:649028-649342 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8676.87 Da Isoelectric Point: 5.6579
>AT226771 WP_249895581.1 NZ_CP088136:1449232-1449471 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENIAGLQELNRITDEHGLLSDDYRTF
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENIAGLQELNRITDEHGLLSDDYRTF
Download Length: 240 bp
>AT226771 NZ_CP122625:649339-649755 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|