Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1408182..1408698 Replicon chromosome
Accession NZ_CP088136
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SCPM-O-B-4515

Toxin (Protein)


Gene name relE Uniprot ID A0A756PF38
Locus tag LRM91_RS06685 Protein ID WP_000220583.1
Coordinates 1408414..1408698 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LRM91_RS06680 Protein ID WP_000212724.1
Coordinates 1408182..1408424 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM91_RS06660 (1403202) 1403202..1404335 + 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -
LRM91_RS06665 (1404319) 1404319..1405437 + 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LRM91_RS06670 (1405434) 1405434..1406174 + 741 WP_000779259.1 KDGP aldolase family protein -
LRM91_RS06675 (1406191) 1406191..1408104 + 1914 WP_001212142.1 BglG family transcription antiterminator -
LRM91_RS06680 (1408182) 1408182..1408424 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRM91_RS06685 (1408414) 1408414..1408698 + 285 WP_000220583.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRM91_RS06690 (1408702) 1408702..1409166 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRM91_RS06695 (1409288) 1409288..1411426 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LRM91_RS06700 (1411835) 1411835..1413483 - 1649 Protein_1309 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10896.62 Da        Isoelectric Point: 9.6743

>T226770 WP_000220583.1 NZ_CP088136:1408414-1408698 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDPPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T226770 NZ_CP122625:c606169-605705 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT226770 WP_000212724.1 NZ_CP088136:1408182-1408424 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT226770 NZ_CP122625:c606504-606169 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A756PF38

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References