Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1301275..1302056 Replicon chromosome
Accession NZ_CP088136
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SCPM-O-B-4515

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag LRM91_RS06115 Protein ID WP_249895556.1
Coordinates 1301565..1302056 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LRM91_RS06110 Protein ID WP_001110452.1
Coordinates 1301275..1301568 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM91_RS06075 (1297329) 1297329..1298231 + 903 WP_020937303.1 YjiK family protein -
LRM91_RS06080 (1298521) 1298521..1298652 - 132 Protein_1188 hypothetical protein -
LRM91_RS06085 (1298764) 1298764..1299012 - 249 Protein_1189 Ig-like domain-containing protein -
LRM91_RS06090 (1299137) 1299137..1299319 + 183 WP_001676222.1 ATP-binding cassette domain-containing protein -
LRM91_RS06095 (1299312) 1299312..1299599 - 288 WP_001541332.1 transcriptional regulator RtsB -
LRM91_RS06100 (1299596) 1299596..1300471 - 876 WP_000921676.1 AraC family transcriptional regulator -
LRM91_RS06105 (1300737) 1300737..1300958 - 222 WP_001576552.1 hypothetical protein -
LRM91_RS06110 (1301275) 1301275..1301568 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LRM91_RS06115 (1301565) 1301565..1302056 + 492 WP_249895556.1 GNAT family N-acetyltransferase Toxin
LRM91_RS06120 (1302304) 1302304..1303056 - 753 WP_000842432.1 non-specific acid phosphatase -
LRM91_RS06125 (1303156) 1303156..1303233 - 78 Protein_1197 porin family protein -
LRM91_RS06130 (1303613) 1303613..1303687 + 75 Protein_1198 helix-turn-helix domain-containing protein -
LRM91_RS06140 (1303958) 1303958..1304533 - 576 WP_001188509.1 transcriptional regulator -
LRM91_RS06145 (1304570) 1304570..1306273 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LRM91_RS06150 (1306249) 1306249..1306596 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17605.42 Da        Isoelectric Point: 7.7028

>T226769 WP_249895556.1 NZ_CP088136:1301565-1302056 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLPGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T226769 NZ_CP122625:183507-183614 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT226769 WP_001110452.1 NZ_CP088136:1301275-1301568 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT226769 NZ_CP122625:c183459-183393 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References