Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 822495..823155 Replicon chromosome
Accession NZ_CP088136
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SCPM-O-B-4515

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LRM91_RS03980 Protein ID WP_000244756.1
Coordinates 822742..823155 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LRM91_RS03975 Protein ID WP_000351186.1
Coordinates 822495..822761 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM91_RS03955 (818424) 818424..819857 - 1434 WP_249895475.1 6-phospho-beta-glucosidase BglA -
LRM91_RS03960 (820015) 820015..820326 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LRM91_RS03965 (820490) 820490..821149 + 660 WP_249895476.1 hemolysin III family protein -
LRM91_RS03970 (821265) 821265..822245 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
LRM91_RS03975 (822495) 822495..822761 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LRM91_RS03980 (822742) 822742..823155 + 414 WP_000244756.1 protein YgfX Toxin
LRM91_RS03985 (823208) 823208..823729 - 522 WP_001055885.1 flavodoxin FldB -
LRM91_RS03990 (823842) 823842..824738 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LRM91_RS03995 (824762) 824762..825475 + 714 WP_249895477.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRM91_RS04000 (825481) 825481..827214 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T226766 WP_000244756.1 NZ_CP088136:822742-823155 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T226766 NZ_CP122623:56090-56368 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
TGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT226766 WP_000351186.1 NZ_CP088136:822495-822761 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT226766 NZ_CP122623:55821-56090 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCACGGCGATGTGCTTCCCCATGACATGGTCGAATCCTCTGCTGCAGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References