Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 199250..200010 Replicon chromosome
Accession NZ_CP088136
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SCPM-O-B-4515

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag LRM91_RS00930 Protein ID WP_000533909.1
Coordinates 199525..200010 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LRM91_RS00925 Protein ID WP_000965886.1
Coordinates 199250..199537 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM91_RS00905 (194655) 194655..195566 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
LRM91_RS00910 (195576) 195576..197645 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LRM91_RS00915 (198035) 198035..198433 + 399 Protein_182 IS3 family transposase -
LRM91_RS00920 (198605) 198605..199072 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
LRM91_RS00925 (199250) 199250..199537 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LRM91_RS00930 (199525) 199525..200010 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
LRM91_RS00935 (200381) 200381..200920 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LRM91_RS00940 (201094) 201094..201306 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LRM91_RS00945 (201594) 201594..201884 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LRM91_RS00950 (202323) 202323..203033 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LRM91_RS00955 (203083) 203083..204057 - 975 WP_000804675.1 glyoxylate/hydroxypyruvate reductase GhrB -
LRM91_RS00960 (204276) 204276..204926 - 651 WP_000747550.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T226763 WP_000533909.1 NZ_CP088136:199525-200010 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T226763 NZ_CP122622:62336-62611 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT226763 WP_000965886.1 NZ_CP088136:199250-199537 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT226763 NZ_CP122622:62052-62336 [Escherichia coli]
ATACAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGTCTCAGTACTGACAATCCGTTACCGGTGCCCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References