Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 13331..13856 | Replicon | plasmid pB-4493_1 |
| Accession | NZ_CP088135 | ||
| Organism | Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4493 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | Q9EUE9 |
| Locus tag | LRM90_RS23390 | Protein ID | WP_001541545.1 |
| Coordinates | 13331..13636 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | LRM90_RS23395 | Protein ID | WP_000813641.1 |
| Coordinates | 13638..13856 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRM90_RS23350 (LRM90_23350) | 8733..9277 | - | 545 | Protein_10 | inverse autotransporter beta domain-containing protein | - |
| LRM90_RS23355 (LRM90_23355) | 9172..9495 | - | 324 | WP_223557582.1 | LysM peptidoglycan-binding domain-containing protein | - |
| LRM90_RS23360 (LRM90_23360) | 10012..10497 | - | 486 | WP_000905606.1 | membrane protein | - |
| LRM90_RS23365 (LRM90_23365) | 10491..10916 | - | 426 | WP_001134680.1 | CaiF/GrlA family transcriptional regulator | - |
| LRM90_RS23370 (LRM90_23370) | 11144..11695 | - | 552 | WP_000545754.1 | EAL domain-containing protein | - |
| LRM90_RS23375 (LRM90_23375) | 11704..12486 | - | 783 | WP_000082169.1 | site-specific integrase | - |
| LRM90_RS23380 (LRM90_23380) | 12521..13042 | - | 522 | WP_000198608.1 | hypothetical protein | - |
| LRM90_RS23385 (LRM90_23385) | 13039..13329 | - | 291 | WP_001266176.1 | hypothetical protein | - |
| LRM90_RS23390 (LRM90_23390) | 13331..13636 | - | 306 | WP_001541545.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| LRM90_RS23395 (LRM90_23395) | 13638..13856 | - | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| LRM90_RS23400 (LRM90_23400) | 14532..15053 | + | 522 | WP_079961209.1 | hypothetical protein | - |
| LRM90_RS23405 (LRM90_23405) | 15097..15525 | - | 429 | Protein_21 | hypothetical protein | - |
| LRM90_RS23410 (LRM90_23410) | 15537..15832 | + | 296 | Protein_22 | cytoplasmic protein | - |
| LRM90_RS23415 (LRM90_23415) | 16326..17315 | + | 990 | WP_000461383.1 | RepB family plasmid replication initiator protein | - |
| LRM90_RS23420 (LRM90_23420) | 17646..17765 | - | 120 | Protein_24 | recombinase | - |
| LRM90_RS23425 (LRM90_23425) | 17818..18204 | - | 387 | WP_001541549.1 | YgiW/YdeI family stress tolerance OB fold protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | spvB / spvC / pefB / pefA / pefC / pefD | 1..49556 | 49556 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11659.54 Da Isoelectric Point: 5.8604
>T226761 WP_001541545.1 NZ_CP088135:c13636-13331 [Salmonella enterica subsp. enterica serovar Gallinarum]
MQFKVYTCKRESRYRLFVDVQSDIIDTPERRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPERRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T226761 NZ_CP122620:c4862793-4862620 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT226761 WP_000813641.1 NZ_CP088135:c13856-13638 [Salmonella enterica subsp. enterica serovar Gallinarum]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT226761 NZ_CP122620:c4863117-4862821 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9EUE9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |