Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3102655..3103469 Replicon chromosome
Accession NZ_CP088134
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4493

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LRM90_RS15010 Protein ID WP_000971655.1
Coordinates 3102655..3103182 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LRM90_RS15015 Protein ID WP_000855694.1
Coordinates 3103179..3103469 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM90_RS14980 (3098954) 3098954..3099352 + 399 Protein_2916 cytoplasmic protein -
LRM90_RS14985 (3099543) 3099543..3099782 + 240 Protein_2917 hypothetical protein -
LRM90_RS14990 (3099939) 3099939..3100607 + 669 WP_001540791.1 hypothetical protein -
LRM90_RS14995 (3100634) 3100634..3101128 + 495 WP_001540790.1 hypothetical protein -
LRM90_RS15000 (3101373) 3101373..3102029 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LRM90_RS15005 (3102367) 3102367..3102582 + 216 Protein_2921 IS5/IS1182 family transposase -
LRM90_RS15010 (3102655) 3102655..3103182 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LRM90_RS15015 (3103179) 3103179..3103469 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LRM90_RS15020 (3103739) 3103739..3103924 - 186 Protein_2924 IS3 family transposase -
LRM90_RS15025 (3104342) 3104342..3104785 - 444 WP_000715102.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LRM90_RS15030 (3105241) 3105241..3105891 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
LRM90_RS15035 (3105888) 3105888..3107576 + 1689 WP_001540787.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3102442..3102582 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T226752 WP_000971655.1 NZ_CP088134:c3103182-3102655 [Salmonella enterica subsp. enterica serovar Gallinarum]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T226752 NZ_CP122620:2796012-2796119 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT226752 WP_000855694.1 NZ_CP088134:c3103469-3103179 [Salmonella enterica subsp. enterica serovar Gallinarum]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT226752 NZ_CP122620:c2795965-2795899 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References