Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2454228..2455019 Replicon chromosome
Accession NZ_CP088134
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4493

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag LRM90_RS11825 Protein ID WP_000369560.1
Coordinates 2454501..2455019 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag LRM90_RS11820 Protein ID WP_001275017.1
Coordinates 2454228..2454497 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM90_RS11800 (2449809) 2449809..2450477 + 669 WP_000617729.1 cell division ATP-binding protein FtsE -
LRM90_RS11805 (2450470) 2450470..2451525 + 1056 WP_001079363.1 permease-like cell division protein FtsX -
LRM90_RS11810 (2451771) 2451771..2452625 + 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
LRM90_RS11815 (2452947) 2452947..2454050 + 1104 WP_001535347.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
LRM90_RS11820 (2454228) 2454228..2454497 + 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
LRM90_RS11825 (2454501) 2454501..2455019 + 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
LRM90_RS11830 (2455016) 2455016..2455399 - 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
LRM90_RS11835 (2455821) 2455821..2456924 + 1104 WP_023235350.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LRM90_RS11840 (2456984) 2456984..2457910 + 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LRM90_RS11845 (2457907) 2457907..2459184 + 1278 WP_001541045.1 branched chain amino acid ABC transporter permease LivM -
LRM90_RS11850 (2459181) 2459181..2459948 + 768 WP_000082080.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T226748 WP_000369560.1 NZ_CP088134:2454501-2455019 [Salmonella enterica subsp. enterica serovar Gallinarum]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

>T226748 NZ_CP122620:2073790-2073893 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT226748 WP_001275017.1 NZ_CP088134:2454228-2454497 [Salmonella enterica subsp. enterica serovar Gallinarum]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp

>AT226748 NZ_CP122620:c2073894-2073660 [Escherichia coli]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References