Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2344318..2345078 Replicon chromosome
Accession NZ_CP088134
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4493

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag LRM90_RS11355 Protein ID WP_000533909.1
Coordinates 2344593..2345078 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LRM90_RS11350 Protein ID WP_000965886.1
Coordinates 2344318..2344605 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM90_RS11325 (2339407) 2339407..2339709 + 303 WP_000605590.1 YsaB family lipoprotein -
LRM90_RS11330 (2339848) 2339848..2340759 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
LRM90_RS11335 (2340769) 2340769..2342838 + 2070 WP_001291737.1 glycine--tRNA ligase subunit beta -
LRM90_RS11340 (2343100) 2343100..2343501 + 402 Protein_2203 IS3 family transposase -
LRM90_RS11345 (2343673) 2343673..2344140 + 468 WP_000702450.1 GNAT family N-acetyltransferase -
LRM90_RS11350 (2344318) 2344318..2344605 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LRM90_RS11355 (2344593) 2344593..2345078 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
LRM90_RS11365 (2346764) 2346764..2347303 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
LRM90_RS11370 (2347477) 2347477..2347689 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LRM90_RS11375 (2347977) 2347977..2348267 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LRM90_RS11380 (2348706) 2348706..2349416 + 711 WP_001541097.1 DUF3053 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T226747 WP_000533909.1 NZ_CP088134:2344593-2345078 [Salmonella enterica subsp. enterica serovar Gallinarum]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T226747 NZ_CP122620:1962076-1962330 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT226747 WP_000965886.1 NZ_CP088134:2344318-2344605 [Salmonella enterica subsp. enterica serovar Gallinarum]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT226747 NZ_CP122620:1961828-1962079 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCATAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References