Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1531341..1531857 Replicon chromosome
Accession NZ_CP088134
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4493

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LRM90_RS07525 Protein ID WP_000220578.1
Coordinates 1531341..1531625 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LRM90_RS07530 Protein ID WP_000212724.1
Coordinates 1531615..1531857 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM90_RS07510 (1526461) 1526461..1528109 + 1649 Protein_1470 alpha,alpha-phosphotrehalase -
LRM90_RS07515 (1528518) 1528518..1530656 + 2139 WP_001541406.1 anaerobic ribonucleoside-triphosphate reductase -
LRM90_RS07520 (1530873) 1530873..1531337 + 465 WP_001009177.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRM90_RS07525 (1531341) 1531341..1531625 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRM90_RS07530 (1531615) 1531615..1531857 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRM90_RS07535 (1531935) 1531935..1533868 - 1934 Protein_1475 BglG family transcription antiterminator -
LRM90_RS07540 (1533885) 1533885..1534625 - 741 WP_000779257.1 KDGP aldolase family protein -
LRM90_RS07545 (1534622) 1534622..1535740 - 1119 WP_038394077.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LRM90_RS07550 (1535724) 1535724..1536857 - 1134 WP_000459940.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T226745 WP_000220578.1 NZ_CP088134:c1531625-1531341 [Salmonella enterica subsp. enterica serovar Gallinarum]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T226745 NZ_CP122620:1059845-1060180 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT226745 WP_000212724.1 NZ_CP088134:c1531857-1531615 [Salmonella enterica subsp. enterica serovar Gallinarum]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT226745 NZ_CP122620:1059597-1059845 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References