Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 771496..772116 Replicon chromosome
Accession NZ_CP088134
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4493

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LRM90_RS03875 Protein ID WP_001280991.1
Coordinates 771898..772116 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LRM90_RS03870 Protein ID WP_000344807.1
Coordinates 771496..771870 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM90_RS03860 (766635) 766635..767828 + 1194 WP_023235518.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LRM90_RS03865 (767851) 767851..771000 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LRM90_RS03870 (771496) 771496..771870 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LRM90_RS03875 (771898) 771898..772116 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LRM90_RS03880 (772295) 772295..772846 + 552 WP_001278793.1 maltose O-acetyltransferase -
LRM90_RS03885 (772964) 772964..773434 + 471 WP_000136183.1 YlaC family protein -
LRM90_RS03890 (773490) 773490..773630 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LRM90_RS03895 (773636) 773636..773896 - 261 WP_223557629.1 type B 50S ribosomal protein L31 -
LRM90_RS03900 (774121) 774121..775530 + 1410 WP_038393950.1 EAL domain-containing protein -
LRM90_RS03910 (775761) 775761..776150 + 390 WP_000961285.1 MGMT family protein -
LRM90_RS03915 (776183) 776183..776752 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T226741 WP_001280991.1 NZ_CP088134:771898-772116 [Salmonella enterica subsp. enterica serovar Gallinarum]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T226741 NZ_CP122620:655479-655793 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT226741 WP_000344807.1 NZ_CP088134:771496-771870 [Salmonella enterica subsp. enterica serovar Gallinarum]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT226741 NZ_CP122620:655790-656206 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References