Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3760152..3760939 Replicon chromosome
Accession NC_010468
Organism Escherichia coli ATCC 8739

Toxin (Protein)


Gene name yeeV Uniprot ID A0A377E3D6
Locus tag ECOLC_RS18500 Protein ID WP_001194695.1
Coordinates 3760562..3760939 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2H9G3E7
Locus tag ECOLC_RS18495 Protein ID WP_000066236.1
Coordinates 3760152..3760511 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECOLC_RS18445 3755392..3755844 + 453 WP_001020418.1 hypothetical protein -
ECOLC_RS18450 3755841..3756293 + 453 WP_000734138.1 hypothetical protein -
ECOLC_RS18455 3756356..3756898 + 543 WP_001104018.1 DUF4339 domain-containing protein -
ECOLC_RS18460 3756957..3757409 + 453 WP_001061894.1 hypothetical protein -
ECOLC_RS18465 3757486..3757719 + 234 WP_001114682.1 DUF905 domain-containing protein -
ECOLC_RS18470 3757839..3758657 + 819 WP_001234406.1 DUF945 domain-containing protein -
ECOLC_RS18480 3758925..3759395 + 471 WP_000131762.1 antirestriction protein -
ECOLC_RS18485 3759407..3759886 + 480 WP_000437750.1 DNA repair protein RadC -
ECOLC_RS18490 3759907..3760128 + 222 WP_000691981.1 DUF987 domain-containing protein -
ECOLC_RS18495 3760152..3760511 + 360 WP_000066236.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECOLC_RS18500 3760562..3760939 + 378 WP_001194695.1 TA system toxin CbtA family protein Toxin
ECOLC_RS18505 3760936..3761427 + 492 WP_000777682.1 hypothetical protein -
ECOLC_RS18510 3761459..3761662 + 204 WP_000413747.1 DUF957 domain-containing protein -
ECOLC_RS18515 3761743..3762587 + 845 Protein_3532 DUF4942 domain-containing protein -
ECOLC_RS18525 3762929..3763660 - 732 WP_001300756.1 DNA polymerase III subunit epsilon -
ECOLC_RS18530 3763725..3764192 + 468 WP_000917883.1 ribonuclease HI -
ECOLC_RS18535 3764189..3764911 - 723 WP_001297210.1 class I SAM-dependent methyltransferase -
ECOLC_RS18540 3764945..3765700 + 756 WP_001052717.1 hydroxyacylglutathione hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14180.97 Da        Isoelectric Point: 7.4209

>T22672 WP_001194695.1 NC_010468:3760562-3760939 [Escherichia coli ATCC 8739]
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR

Download         Length: 378 bp

>T22672 NC_010468:3760562-3760939 [Escherichia coli ATCC 8739]
ATGCAAACCCAACCACTATCCTCAACGCAGGAGGCTACATCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACGCTTAACGACACGCCGTTTGGCAACGACGGTGTGATTCAGGAGCATATCG
ACGCCGGTATATCACTGTGCGACGCCGTGAATTTTATTGTGGAGAAGTACGATCTGGTGCGCATCGATCGTCACGGTTTC
AGTACAGAAACACAGTTGCCGCGTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGTTGATGACTCGCAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGTGGGGGGCATCGATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13127.02 Da        Isoelectric Point: 7.0261

>AT22672 WP_000066236.1 NC_010468:3760152-3760511 [Escherichia coli ATCC 8739]
MSNKIPTVNHDITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA

Download         Length: 360 bp

>AT22672 NC_010468:3760152-3760511 [Escherichia coli ATCC 8739]
TTGTCGAATAAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTGCAGTCGGGCAACTGTCTGCATTATCTCGCTGACCGGGCCAGCATCACCGGACAGTTCAGCGACG
GGGATTTACGGCATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCACT
CCCCGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377E3D6

Antitoxin

Source ID Structure
AlphaFold DB A0A2H9G3E7

References