Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4695755..4696271 Replicon chromosome
Accession NZ_CP088126
Organism Klebsiella pneumoniae strain 57

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LRM34_RS23030 Protein ID WP_002886902.1
Coordinates 4695755..4696039 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LRM34_RS23035 Protein ID WP_002886901.1
Coordinates 4696029..4696271 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM34_RS23005 (LRM34_23005) 4691239..4691502 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LRM34_RS23010 (LRM34_23010) 4691632..4691805 + 174 WP_002886906.1 hypothetical protein -
LRM34_RS23015 (LRM34_23015) 4691808..4692551 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LRM34_RS23020 (LRM34_23020) 4692908..4695046 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LRM34_RS23025 (LRM34_23025) 4695287..4695751 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRM34_RS23030 (LRM34_23030) 4695755..4696039 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRM34_RS23035 (LRM34_23035) 4696029..4696271 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRM34_RS23040 (LRM34_23040) 4696349..4698259 - 1911 WP_004152270.1 PRD domain-containing protein -
LRM34_RS23045 (LRM34_23045) 4698282..4699436 - 1155 WP_002886900.1 lactonase family protein -
LRM34_RS23050 (LRM34_23050) 4699502..4700242 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T226709 WP_002886902.1 NZ_CP088126:c4696039-4695755 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T226709 NZ_CP122604:c4370012-4369725 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT226709 WP_002886901.1 NZ_CP088126:c4696271-4696029 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT226709 NZ_CP122604:c4369738-4369436 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References