Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3919679..3920336 Replicon chromosome
Accession NZ_CP088119
Organism Enterobacter kobei strain 6

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag LRM31_RS18580 Protein ID WP_014885136.1
Coordinates 3919679..3920089 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag LRM31_RS18585 Protein ID WP_010435322.1
Coordinates 3920070..3920336 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM31_RS18560 (LRM31_18560) 3915673..3917406 - 1734 WP_047027281.1 single-stranded-DNA-specific exonuclease RecJ -
LRM31_RS18565 (LRM31_18565) 3917412..3918125 - 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRM31_RS18570 (LRM31_18570) 3918154..3919050 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
LRM31_RS18575 (LRM31_18575) 3919152..3919673 + 522 WP_047027280.1 flavodoxin FldB -
LRM31_RS18580 (LRM31_18580) 3919679..3920089 - 411 WP_014885136.1 protein YgfX Toxin
LRM31_RS18585 (LRM31_18585) 3920070..3920336 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
LRM31_RS18590 (LRM31_18590) 3920631..3921611 + 981 WP_047027279.1 tRNA-modifying protein YgfZ -
LRM31_RS18595 (LRM31_18595) 3921696..3922355 - 660 WP_241448876.1 hemolysin III family protein -
LRM31_RS18600 (LRM31_18600) 3922621..3923352 + 732 WP_014885139.1 MurR/RpiR family transcriptional regulator -
LRM31_RS18605 (LRM31_18605) 3923469..3924902 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T226667 WP_014885136.1 NZ_CP088119:c3920089-3919679 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T226667 NZ_CP122595:c25813-25553 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCTGATCTTGTTTTTCATGAGGAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT226667 WP_010435322.1 NZ_CP088119:c3920336-3920070 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT226667 NZ_CP122595:c25563-25312 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCTGAAAT
ATTCAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References